IKZF

IKZF (Ikaros zinc finger) is a family of transcription factors that play a key role in lymphocyte development and immune system function, mainly including Ikaros (IKZF1), Aiolos (IKZF3), Helios (IKZF2), Eos (IKZF4), and Hobit (IKZF5).IkZF family Members contain an N-terminal zinc finger (ZF) DNA-binding domain and a C-terminal ZF protein-protein interaction domain, which positively and negatively regulate gene expression by interacting directly with DNA and by forming transcriptional complexes with other proteins, and have been implicated in leukemias, lymphomas, and immune responses of B and T cells.