Shopping Cart

Your shopping cart is currently empty

Lorglumide sodium salt

Name: Lorglumide sodium salt
Brand: TargetMol
SKU: T11868
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T11868Cas No. 1021868-76-7

Alias CR-1409 sodium salt

Lorglumide sodium salt (CR-1409 sodium salt) is an antagonist of cholecystokinin receptors (CCK).

Lorglumide sodium salt

Copy Product Info

😃Good

Purity: 99.32%

Catalog No. T11868Alias CR-1409 sodium saltCas No. 1021868-76-7

Lorglumide sodium salt (CR-1409 sodium salt) is an antagonist of cholecystokinin receptors (CCK).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$29	In Stock	In Stock
10 mg	$43	-	In Stock
25 mg	Preferential	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.32%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Lorglumide sodium salt AI Summary

Lorglumide sodium salt exhibits a multifaceted range of bioactivities, demonstrating potent inhibition in several biological processes including Lamin A splicing, ALDH1A1 inhibition, Influenza NS1 Protein function inhibition, Histone Lysine Methyltransferase G9a inhibition, Polymerase Iota inhibition, TGF-b inhibition, ATXN expression blocking, and Ebola Virus entry inhibition, with activities noted in the low nanomolar and micromolar ranges. Additionally, the compound inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells, with inhibition percentages of 32.85% and 16.54%, and Ki values of 2710.0 nM and 2010.0 nM respectively. Lorglumide sodium salt also demonstrates moderate affinity for the CCK-A receptor with an IC50 of 170.0 nM and exhibits antiproliferative activities against various cancer cell lines (MiaPaCa, AGS, PANC, and MAC13) with IC50 values ranging from 289.0 to 421.0 nM. Furthermore, it shows activity in inhibiting cell viability in SARS-CoV-2-infected Vero E6 cells at an MOI of 0.002 after 72 hours, with an inhibition index of 0.5123 relative to arbidol control. These findings indicate its potential for diverse therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Lorglumide sodium salt (CR-1409 sodium salt) is an antagonist of cholecystokinin receptors (CCK).
Synonyms	CR-1409 sodium salt

Chemical Properties

Molecular Weight	481.39
Formula	C₂₂H₃₁Cl₂N₂NaO₄
Cas No.	1021868-76-7
Smiles	CCCCCN(C(C(NC(C1=CC(Cl)=C(Cl)C=C1)=O)CCC([O-])=O)=O)CCCCC.[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (186.96 mM), Sonication is recommended.

H2O: 100 mg/mL (207.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0773 mL	10.3866 mL	20.7732 mL	103.8659 mL
5 mM	0.4155 mL	2.0773 mL	4.1546 mL	20.7732 mL
10 mM	0.2077 mL	1.0387 mL	2.0773 mL	10.3866 mL
20 mM	0.1039 mL	0.5193 mL	1.0387 mL	5.1933 mL
50 mM	0.0415 mL	0.2077 mL	0.4155 mL	2.0773 mL
100 mM	0.0208 mL	0.1039 mL	0.2077 mL	1.0387 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc