Shopping Cart

Your shopping cart is currently empty

EMD57033

Name: EMD57033
Brand: TargetMol
SKU: T25372
Price: 318 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T25372Cas No. 147527-31-9

Alias EMD-57033, EMD 57033, (+)-EMD 57033

EMD57033 is a cardiac troponin C (cTnC) activator, a dominant Ca2+ sensitizer, which functions by binding to cardiac/slow skeletal troponin C heterodimers to promote cardiac contraction.

EMD57033

🥰Excellent

Purity: 99.11%

Catalog No. T25372Alias EMD-57033, EMD 57033, (+)-EMD 57033Cas No. 147527-31-9

EMD57033 is a cardiac troponin C (cTnC) activator, a dominant Ca2+ sensitizer, which functions by binding to cardiac/slow skeletal troponin C heterodimers to promote cardiac contraction.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$318	In Stock	In Stock
5 mg	$753	In Stock	In Stock
10 mg	$987	In Stock	In Stock
25 mg	$1,530	In Stock	In Stock
50 mg	$1,980	In Stock	In Stock
100 mg	$2,500	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.11%

ee:99.58%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR CSFC ORP

Product Introduction

Bioactivity

Description	EMD57033 is a cardiac troponin C (cTnC) activator, a dominant Ca2+ sensitizer, which functions by binding to cardiac/slow skeletal troponin C heterodimers to promote cardiac contraction.
In vitro	EMD57033 (5.0 to 5.8 mumol/L) enhances contractility and prolongs relaxation. Its effects are modulated by heart rate, [Ca2+]o, and contraction mode, with positive inotropic effects being more prominent for ejecting beats.[4]
In vivo	EMD-57033 (0.4 mg. kg(-1). min(-1) for 20 minutes) selective Ca(2+) sensitization with minimal PDE3I in vivo is achieved, improving basal and rate-stimulated contractility and mechanoenergetics of HF without compromising diastolic function. Despite PDE3I activity at higher doses, energetic benefits persist.[5]
Synonyms	EMD-57033, EMD 57033, (+)-EMD 57033

Chemical Properties

Molecular Weight	425.5
Formula	C₂₂H₂₃N₃O₄S
Cas No.	147527-31-9
Smiles	O=C(C1=CC(OC)=C(C=C1)OC)N2C3=CC=C(C([C@H](S4)C)=NNC4=O)C=C3CCC2
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (117.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3502 mL	11.7509 mL	23.5018 mL	117.5088 mL
5 mM	0.4700 mL	2.3502 mL	4.7004 mL	23.5018 mL
10 mM	0.2350 mL	1.1751 mL	2.3502 mL	11.7509 mL
20 mM	0.1175 mL	0.5875 mL	1.1751 mL	5.8754 mL
50 mM	0.0470 mL	0.2350 mL	0.4700 mL	2.3502 mL
100 mM	0.0235 mL	0.1175 mL	0.2350 mL	1.1751 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc