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ccc_R08

Name: ccc_R08
Brand: TargetMol
SKU: T73440
Price: 159 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T73440Cas No. 2919019-72-8

ccc_R08 is an orally available HBV cccDNA inhibitor that reduces extracellular levels of HBV DNA, HBsAg, and HBeAg in a dose-dependent manner. ccc_R08 is investigational for use in the treatment of HBV infections. ccc_R08 has been shown to be effective in the treatment of hepatitis C virus (HCV).

ccc_R08

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Purity: 99.86%

Catalog No. T73440Cas No. 2919019-72-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$159	-	In Stock
5 mg	$355	-	In Stock
10 mg	$533	-	In Stock
25 mg	$1,120	-	In Stock
50 mg	$1,490	-	In Stock
100 mg	$1,980	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ccc_R08 is an orally available HBV cccDNA inhibitor that reduces extracellular levels of HBV DNA, HBsAg, and HBeAg in a dose-dependent manner. ccc_R08 is investigational for use in the treatment of HBV infections. ccc_R08 has been shown to be effective in the treatment of hepatitis C virus (HCV).
In vitro	In HepDES19 cells, ccc_R08 (0.3, 1.0, 3.2, 10, 32 µM; 5 days) reduced the levels of cccDNA, protein-free RC-DNA, and double-stranded linear DNA (DL-DNA)[1].
In vivo	In the HBV circle mouse model, ccc_R08 (20 mg/kg; oral administration; twice daily for 2 weeks) led to the clearance of cccDNA from the livers of HBV circle mice[1].

Chemical Properties

Molecular Weight	414.84
Formula	C₂₂H₁₉ClO₆
Cas No.	2919019-72-8
Smiles	O=C(O)C1CC(OCCOC=2C=CC(=CC2)C=3OC=4C(Cl)=CC=CC4C(=O)C3)C1
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (192.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4106 mL	12.0528 mL	24.1057 mL	120.5284 mL
5 mM	0.4821 mL	2.4106 mL	4.8211 mL	24.1057 mL
10 mM	0.2411 mL	1.2053 mL	2.4106 mL	12.0528 mL
20 mM	0.1205 mL	0.6026 mL	1.2053 mL	6.0264 mL
50 mM	0.0482 mL	0.2411 mL	0.4821 mL	2.4106 mL
100 mM	0.0241 mL	0.1205 mL	0.2411 mL	1.2053 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc