nc

NC-1300-B inhibits H(+)-K(+)-ATPase and is used in the study of gastric ulcers.

NC00075159 is an opener of human KCNQ4 (Kv7.4) potassium channel.

NC043 is an inhibitor of Wnt/β-catenin signaling, it forms a covalent bond with the Cys-516 residue of CARF.

Primordazine NC-6364997 is a negative control for Primordazine A and Primordazine B.

NC1 is a novel highly active allosteric inhibitor of protein tyrosine phosphatase, non-receptor type 22 (PTPN22) which is a lymphoid-specific tyrosine phosphatase (LYP).

NC-2100 is an aperoxisome proliferator-activated receptor-gamma (PPARgamma) activator.

NC03 is an effective PI4K2A inhibitor that reduces intracellular PI4P pools in the Golgi apparatus and endosomes, with PI4K2A being the primary source of PI4P. NC03 may be utilised in cancer research.

Eprodisate disodium (NC-503) is a negatively charged sulfonated inhibitor of fibrillogenesis, used in the treatment of amyloid A (AA) amyloidosis.

Vecuronium bromide (ORG NC 45) is a synthetic, intermediate-acting, mono-quaternary steroid that functions as a non-depolarizing neuromuscular blocking agent with muscle relaxant properties.

Neotame (HSDB 7965) is a white-colored, dipeptide methyl ester, which is found to be a highly potent and non-nutritive sweetener or flavour enhancer and hence finds applications in a variety of foods.

Ipenoxazone is an effective and centrally acting muscle relaxant.

Quizalofop-ethyl (NC 302) is a aryloxyphenoxypropionate herbicide used for post-emergence control of annual and perennial grass weeds within broadleaf crops such as soybeans, cotton, and peanuts, and its herbicidal activity is mediated through the potent inhibition of the acetyl-CoA carboxylase (ACCase) enzyme.

Iptriazopyrid (NC-656) is a triazole carboxamide herbicide that targets 4-hydroxyphenylpyruvate dioxygenase (HPPD). It exhibits a Ki value of 24.3 nM for Arabidopsis HPPD and 33.3 nM for rice HPPD. By inhibiting the synthesis of plastoquinone and carotenoids, Iptriazopyrid causes weed yellowing and death. It shows promise in research for controlling paddy field weeds such as barnyard grass.

Mesoridazine (thioridazine EP impurity B) is a phenothiazine antipsychotic with effects similar to chlorpromazine.

GI261520A is a potent egfr/erbb2 dual inhibitor

Bevantolol hydrochloride (NC-1400 hydrochloride) is a β1-adrenoceptor antagonist that treatment angina pectoris and hypertension.

SIAIS630121-NC serves as the negative control for the degradation product SIAIS630121 of NAMPT (nicotinamide phosphoribosyltransferase).

SIAIS630120-NC is the negative control for the degradation product of NAMPT (nicotinamide phosphoribosyltransferase), known as SIAIS630120.

SGC-BRDVIII-NC (Compound 35) serves as a negative control for the SMARCA2/4 and PB1 bromodomain (BRD) inhibitors. The binding ability of the protein-ligand is completely eliminated in SGC-BRDVIII-NC through the methylation of the phenolic hydroxyl group. This compound is applicable for research in adipogenesis.

MRK-740-NC is an inhibitor of the PRDM7/9 histone methyltransferase. Acting as the negative control compound for MRK-740, MRK-740-NC lacks inhibitory activity on PRDM7 and PRDM9 because the methylpyridine portion of MRK-740 is replaced with a phenyl group.

NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor with significant affinity for various BRD4 and BRDT isoforms, as demonstrated by its Kd values of 0.095 nM for BRD4-1, 0.32 nM for BRD4-2, 0.29 nM for BRD4-T, 0.089 nM for BRDT-1, 5.5 nM for BRDT-2, and 0.058 nM for BRDT-T. Additionally, NC-III-49-1 exhibits antiproliferative effects and reduces the expression of c-Myc [1].

NC-R17, an RSL3-based noncovalent GPX4 degrader implicated in ferroptosis, demonstrates anti-tumor activity and is utilized in the design of noncovalent GPX4-targeted proteolysis targeting chimeras (PROTACs) [1].

Tamolarizine (Tamolarizine free base) free base is a novel calcium antagonist.

Tropantiol (also known as NC100697) is a chelating agent that has been utilized for the diagnosis or exclusion of Parkinson's syndrome and its accompanying dopamine deficiency.