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Tamolarizine

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Catalog No. T34782Cas No. 93035-32-6
Alias Tamolarizine free base, Tamolarizine, NC-1100, NC1100, NC 1100

Tamolarizine (Tamolarizine free base) free base is a novel calcium antagonist.

Tamolarizine
Other Forms of Tamolarizine:
NC 1100T2585493035-33-7
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Tamolarizine

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Purity: 97.73%
Catalog No. T34782Alias Tamolarizine free base, Tamolarizine, NC-1100, NC1100, NC 1100Cas No. 93035-32-6
Tamolarizine (Tamolarizine free base) free base is a novel calcium antagonist.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$86In StockIn Stock
5 mg$216In StockIn Stock
10 mg$318In StockIn Stock
25 mg$515In StockIn Stock
50 mg$747In StockIn Stock
100 mg$1,050In StockIn Stock
200 mg$1,420-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:97.73%
Appearance:Solid
Color:White
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Tamolarizine (Tamolarizine free base) free base is a novel calcium antagonist.
In vitro
Tamolarizine (0.1-10 microM) synergistically potentiated the cytotoxicity of doxorubicin for doxorubicin-resistant K562 cells (K562/DXR), but had hardly any synergistic effects in the parental cell line (K562) at the same concentration. Moreover, tamolarizine inhibits the P-glycoprotein pump-efflux activity in a dose-related manner and reduces the expression of the immunoreactive P-glycoprotein in K562/DXR cells as evaluated by cytofluorimetric assay.[1]
In vivo
Tamolarizine (40 mg/kg; rats; immediately after 15-min brain ischemia) showed slight impairment of place learning during the course of this test, they later reached almost the same performance level as the sham-operated group. Selective neuronal loss in the CA1 subfield was much less in the ischemia+tamolarizine group than in the ischemia+saline group. These results indicate that tamolarizine treatment protects the hippocampus from ischemic brain damage and ameliorates place learning impairment.[2]
SynonymsTamolarizine free base, Tamolarizine, NC-1100, NC1100, NC 1100
Chemical Properties
Molecular Weight432.55
FormulaC27H32N2O3
Cas No.93035-32-6
SmilesC(N1CCN(CC(O)C2=CC(OC)=C(OC)C=C2)CC1)(C3=CC=CC=C3)C4=CC=CC=C4
Relative Density.1.152 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

CalciumChannelCalcium Channel
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