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4-methoxylonchocarpin

Catalog No. TN7235 CAS 51589-67-4

4-methoxylonchocarpin was isolated from the roots of Abrus precatorius as a potent anti-inflammatory compound. 4-methoxylonchocarpin inhibited NF-κB-activated TNF expression by inhibiting the binding of LPS to TLR4 in macrophages and suppressed TNBS-induced colitis in mice.

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4-methoxylonchocarpin Chemical Structure

4-methoxylonchocarpin, CAS 51589-67-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 490.00
10 mg	In stock	$ 715.00
25 mg	In stock	$ 1,090.00
50 mg	In stock	$ 1,480.00

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Description	4-methoxylonchocarpin was isolated from the roots of Abrus precatorius as a potent anti-inflammatory compound. 4-methoxylonchocarpin inhibited NF-κB-activated TNF expression by inhibiting the binding of LPS to TLR4 in macrophages and suppressed TNBS-induced colitis in mice.
In vitro	The roots of Abrus precatorius (AP, Fabaceae) have traditionally been used in Vietnam and China for the treatment of inflammatory diseases such as stomatitis, asthma, bronchitis, and hepatitis. In this study, we isolated 4-methoxylonchocarpin (ML). In lipopolysaccharide (LPS)-stimulated macrophages, ML was found to inhibit nuclear factor (NF)-κB activation and tumor necrosis factor (TNF) and interleukin (IL)-6 expression by inhibiting LPS binding to Toll-like receptor 4 (TLR4) in vitro.[1]
In vivo	Oral administration of 4-methoxylonchocarpin (ML) in mice with TNBS-induced colitis suppressed colon shortening and colonic myeloperoxidase activity. ML treatment significantly inhibited the activation of nuclear factor (NF)-κB and phosphorylation of transforming growth factor β-activated kinase 1 in the colon. Treatment with ML also inhibited TNBS-induced expression of IL-1β, IL-17A, and TNF. While ML reduced the TNBS-induced expression of M1 macrophage markers such as arginase-2 and TNF, it was found to increase the expression of M2 macrophage markers such as arginase-1 and IL-10. In conclusion, oral administration of ML attenuated colitis in mice by inhibiting the binding of LPS to TLR4 on immune cells and increasing the polarization of M1 macrophages to M2 macrophages.[1]

Molecular Weight	336.38
Formula	C21H20O4
CAS No.	51589-67-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Jang HM, et al. 4-Methoxylonchocarpin attenuates inflammation by inhibiting lipopolysaccharide binding to Toll-like receptor of macrophages and M1 macrophage polarization. Int Immunopharmacol. 2017;45:90-97. 2. Li J, Kang Z, et al. Potent insecticidal activity of Eleocharis dulcis (Burm. f.) Trin peel extract and its main components against aphids. Pest Manag Sci. 2023;79(4):1295-1304. 3. Ngadjui BT, et al. Prenylated flavonoids from the aerial parts of Dorstenia mannii. Phytochemistry. 2000;55(8):915-919. 4. Hussain H, et al. 4-Benzyloxylonchocarpin and Muracatanes A-C from Ranunculus muricatus L. and Their Biological Effects. Biomolecules. 2020;10(11):1562.

Related compound libraries

This product is contained In the following compound libraries：

Immunology/Inflammation Compound Library Rare Natural Product Library

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Keywords

4-methoxylonchocarpin 51589-67-4 Apoptosis NF-Κb TNF NF-κB inhibitor inhibit

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