4-methylumbelliferyl

4-Methylumbelliferyl β-D-N,N'-diacetylchitobioside (4-μU-(GlcNAc)2) is a fluorogenic substrate for chitinases and chitobiosidases. 4-μU-(GlcNAc)2 is cleaved by chitinases and chitobiosidases to release the fluorescent moiety 4-μU. 4-μU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.

4-Methylumbelliferyl caprylate (MUCAP) is a fluorogenic substrate for C8 esterase. MUCAP is cleaved by C8 esterase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.

4-Methylumbelliferyl β-D-glucuronide is a useful organic compound for research related to life sciences. The catalog number is T65323 and the CAS number is 6160-80-1.

4-Methylumbelliferyl elaidate is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

4-Mmethylumbelliferyl α-L-arabinopyranoside (4-Mmethylumbelliferyl α-L-arabinopyranoside) serves as a substrate for enzymes that hydrolyze arabinose-containing substrates, such as α-L-arabinopyranoside.

4-Methylumbelliferyl β-L-fucoside has potential applications in glycobiology research.

4-Methylumbelliferyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside is a reagent used in biochemical reactions.

4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-galactopyranoside is a fluorescent substrate employed to study the enzymatic activity of α-galactosidase. It is utilized for assessing enzyme activity in various biological samples, aiding scientists in understanding the enzyme's role within organisms. Additionally, it serves in screening potential compounds for inhibiting or activating this enzyme.

4-Methylumbelliferyl stearate is a biochemical reagent.

4-Methylumbelliferyl a-L-idopyranosiduronic acid 2-sulphate disodium is a reagent used in biochemical reactions.

4-Methylumbelliferyl-β-D-Glucopyranoside (4-MU-GLU) is used in the GCase activity assay based on the catalytic hydrolysis of 4-methylumbelliferyl β-D-glucopyranoside that releases the highly fluorescent 4-methylumbelliferyl (4-MU).

Mu-6S-Palm-β-Glc is a fluorogenic substrate of palmitoyl-protein thioesterase (PPT, also known as CLN1), a lysosomal hydrolase that removes long-chain fatty acyl groups from modified cysteine residues in proteins. Upon cleavage by PPT/CLN1, it releases the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent, with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. This substrate is used in assays measuring PPT activity, commonly deficient in the neurodegenerative disorder known as infantile neuronal ceroid lipofuscinosis.

4-Methylumbelliferyl-α-L-Iduronide is a common substrate for α-L-iduronidase catalytic activity.

4-Methylumbelliferyl-α-D-Galactopyranoside (4MU-α-Gal) (4-MU-α-Gal) is a fluorogenic substrate of α-galactosidase. In addition to its use in characterizing novel α-galactosidases, 4-MU-α-Gal is used in assays to evaluate deficiency in α-galactosidase activity related to Fabry disease.

4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside is a fluorogenic substrate for β-hexosaminidases. Upon enzymatic cleavage by β-hexosaminidases, 4-methylumbelliferone (4-μU) is released, and its fluorescence quantifies β-hexosaminidase activity. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. This compound has been used to quantify β-hexosaminidase activity in serum or leukocytes from patients with GM2 gangliosidoses, such as Tay-Sachs disease, which is characterized by defects in the α subunit of β-hexosaminidase.

4-Methylumbelliferyl-β-D-N,N',N''-triacetylchitotrioside is a fluorogenic substrate for chitinases and chitotriosidases. 4-Methylumbelliferyl-β-D-N,N',N''-triacetylchitotrioside is cleaved by chitinases and chitotriosidases to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. It has been used to screen plasma samples for reduced chitotriosidase activity that may be indicative of lysosomal storage disorders.

4-Methylumbelliferyl-β-D-xylopyranoside (4-Methylumbelliferyl-β-D-xyloside) exhibits bursting steady-state kinetics in biological experiments, which supports the conclusion of rapid hydrolysis of the glycosidic bond of the substrate 4-Methylumbelliferyl-β-D-xylopyranoside 4-Methylumbelliferyl-β-D-xylopyranoside can be used for β- xylosidase activity studies.

4-Methylumbelliferyl-α-D-Glucopyranoside (4MU-αGlc) is a pH-dependent α-glucosidase fluorometric substrate, a biomarker for Fabry and Pompe diseases, quantifying α-glucosidase activity in infant blood spots.

4-Methylumbelliferyl-β-D-lactoside has potential applications in glycobiology research.

4-Methylumbelliferyl-N-acetyl-β-D-galactosaminide serves as a detection substrate for β-galactosaminidase.

4-Methylumbelliferyl β-D-ribofuranoside is a fluorescent substrate for β-ribosidase.

4-Methylumbelliferyl-α-L-rhamnopyranoside is a biochemical reagent utilized in glycobiology research. Glycobiology examines the structure, synthesis, biology, and evolution of sugars, involving carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the functional roles of glycans in biological systems. This field is closely linked with fundamental research, biomedicine, and biotechnology.

4-Methylumbelliferyl 2-Amino-2-deoxy-α-D-glucopyranoside is a reagent used in biochemical reactions.

4-Methylumbelliferyl 2,3,4,6-Tetra-O-acetyl-α-D-glucopyranoside is a reagent used in biochemical reactions.