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7-Acetoxy-4-methylcoumarin

Name: 7-Acetoxy-4-methylcoumarin
Brand: TargetMol
SKU: T7037
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7037Cas No. 2747-05-9

Alias MU-Ac

7-Acetoxy-4-methylcoumarin is a fluorescent substrate for carboxylesterases and acts as an inhibitor of GST, which can be isolated from Trigonella foenum graceum and inhibits AFB1-DNA binding.

7-Acetoxy-4-methylcoumarin

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Purity: 97.10%

Catalog No. T7037Alias MU-AcCas No. 2747-05-9

7-Acetoxy-4-methylcoumarin is a fluorescent substrate for carboxylesterases and acts as an inhibitor of GST, which can be isolated from Trigonella foenum graceum and inhibits AFB1-DNA binding.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	-	In Stock
500 mg	$42	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:97.10%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	7-Acetoxy-4-methylcoumarin is a fluorescent substrate for carboxylesterases and acts as an inhibitor of GST, which can be isolated from Trigonella foenum graceum and inhibits AFB1-DNA binding.
In vitro	METHODS: A pair of peptides with 18 amino acid residues spanning Lys201 (K201 peptide) and another with 20 residues containing Lys334 (K334 peptide) were synthesized and analyzed using high-performance LC-MS/MS to demonstrate the acetylation effect of 7-Acetoxy-4-methylcoumarin on both peptides. RESULTS 7-Acetoxy-4-methylcoumarin effectively acetylated Lys201 and Lys334 in each peptide, and the amount of acetylated peptide increased in a 7-Acetoxy-4-methylcoumarin dose-dependent manner. [1]
Synonyms	MU-Ac

Chemical Properties

Molecular Weight	218.21
Formula	C₁₂H₁₀O₄
Cas No.	2747-05-9
Smiles	CC(=O)Oc1ccc2c(C)cc(=O)oc2c1
Relative Density.	1.263g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (206.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5827 mL	22.9137 mL	45.8274 mL	229.1371 mL
5 mM	0.9165 mL	4.5827 mL	9.1655 mL	45.8274 mL
10 mM	0.4583 mL	2.2914 mL	4.5827 mL	22.9137 mL
20 mM	0.2291 mL	1.1457 mL	2.2914 mL	11.4569 mL
50 mM	0.0917 mL	0.4583 mL	0.9165 mL	4.5827 mL
100 mM	0.0458 mL	0.2291 mL	0.4583 mL	2.2914 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc