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7-Acetoxy-4-methylcoumarin

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Catalog No. T7037Cas No. 2747-05-9
Alias MU-Ac

7-Acetoxy-4-methylcoumarin is a fluorescent substrate for carboxylesterases and acts as an inhibitor of GST, which can be isolated from Trigonella foenum graceum and inhibits AFB1-DNA binding.

7-Acetoxy-4-methylcoumarin

7-Acetoxy-4-methylcoumarin

😃Good
Purity: 97.10%
Catalog No. T7037Alias MU-AcCas No. 2747-05-9
7-Acetoxy-4-methylcoumarin is a fluorescent substrate for carboxylesterases and acts as an inhibitor of GST, which can be isolated from Trigonella foenum graceum and inhibits AFB1-DNA binding.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
200 mg$29-In Stock
500 mg$42-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.10%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
7-Acetoxy-4-methylcoumarin is a fluorescent substrate for carboxylesterases and acts as an inhibitor of GST, which can be isolated from Trigonella foenum graceum and inhibits AFB1-DNA binding.
In vitro
METHODS: A pair of peptides with 18 amino acid residues spanning Lys201 (K201 peptide) and another with 20 residues containing Lys334 (K334 peptide) were synthesized and analyzed using high-performance LC-MS/MS to demonstrate the acetylation effect of 7-Acetoxy-4-methylcoumarin on both peptides.
RESULTS 7-Acetoxy-4-methylcoumarin effectively acetylated Lys201 and Lys334 in each peptide, and the amount of acetylated peptide increased in a 7-Acetoxy-4-methylcoumarin dose-dependent manner. [1]
SynonymsMU-Ac
Chemical Properties
Molecular Weight218.21
FormulaC12H10O4
Cas No.2747-05-9
SmilesCC(=O)Oc1ccc2c(C)cc(=O)oc2c1
Relative Density.1.263g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (206.22 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2 mg/mL (9.17 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.5827 mL22.9137 mL45.8274 mL229.1371 mL
5 mM0.9165 mL4.5827 mL9.1655 mL45.8274 mL
10 mM0.4583 mL2.2914 mL4.5827 mL22.9137 mL
20 mM0.2291 mL1.1457 mL2.2914 mL11.4569 mL
50 mM0.0917 mL0.4583 mL0.9165 mL4.5827 mL
100 mM0.0458 mL0.2291 mL0.4583 mL2.2914 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

GST7-Acetoxy-4-methylcoumarin7Acetoxy4methylcoumarin7 Acetoxy 4 methylcoumarin
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