Shopping Cart

Your shopping cart is currently empty

Chloranil

Name: Chloranil
Brand: TargetMol
SKU: T80673
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T80673Cas No. 118-75-2

Alias p-Chloranil

Chloranil (tetrachloro-p-benzoquinone) triggers inflammation and neurological dysfunction through Toll-like receptor 4 signaling and can be used to model inflammation in mice.

Chloranil

Copy Product Info

🥰Excellent

Purity: 98.03%

Catalog No. T80673Alias p-ChloranilCas No. 118-75-2

Chloranil (tetrachloro-p-benzoquinone) triggers inflammation and neurological dysfunction through Toll-like receptor 4 signaling and can be used to model inflammation in mice.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.03%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS CNMR

Product Introduction

Chloranil AI Summary

Chloranil exhibits notable bioactivity across a variety of biological targets and pathogens. It functions as an inhibitor of several esterases and cholinesterases, with inhibition constants (Ki) of 57.4 nM, 83.9 nM, and 54.8 nM against human intestinal carboxylesterase 2, human liver carboxylesterase 1, and rabbit liver carboxylesterase, respectively. It also inhibits human Acetylcholinesterase and Butyrylcholinesterase with Ki values of 163.0 nM and 268.0 nM. Additionally, Chloranil shows antiparasitic activity against Trichomonas vaginalis strains T1 and G3 with 12.0% and 40.0% inhibition at 100 µM, respectively. The compound demonstrates cytotoxicity against cancer cells and inhibition of cellular functions such as DNA helicase, hormone receptors, and kinase signaling pathways. It exhibits toxicity against Trichoplusia ni larvae with a 10.0% mortality rate at 10 µg/ml and a feeding deterrence effect of 35.8% at 50 µg/cm². In cellular transport assays, Chloranil inhibits the uptake of sodium fluorescein in OATP1B3- and OATP1B1-transfected CHO cells by 74.83% and 80.53%, respectively. Remarkably, Chloranil has antimalarial activity against chloroquine-sensitive Plasmodium falciparum with an IC50 of 22400.0 nM and a selectivity index greater than 4.4 against human MRC5 cells. It strongly inhibits the refolding activity of GroEL/GroES proteins in Escherichia coli, resulting in a 92.0% reduction in enzyme activity in both rhodanese and soluble pig heart MDH assays. In addition to its enzymatic inhibition properties, Chloranil exhibits significant antiviral activity against SARS-CoV-2. It inhibits the SARS-CoV-2 3CL-Pro protease with an IC50 of less than 20.0 nM, achieving 102.77% inhibition at 20 µM. Moreover, it reduces SARS-CoV-2 induced cytotoxicity in VERO-6 cells, though its IC50 values in this context are greater than 20000.0 nM. Notably, the compound also shows inhibition in FRET-based protease assays with an IC50 of less than 0.02 µM. Overall, Chloranil is a versatile bioactive molecule with potential applications in combating diseases caused by different pathogens, including parasites and viruses, as well as being useful in enzymatic inhibition and cytotoxicity assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Chloranil (tetrachloro-p-benzoquinone) triggers inflammation and neurological dysfunction through Toll-like receptor 4 signaling and can be used to model inflammation in mice.
Synonyms	p-Chloranil

Chemical Properties

Molecular Weight	245.88
Formula	C₆Cl₄O₂
Cas No.	118-75-2
Smiles	ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (203.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0670 mL	20.3351 mL	40.6702 mL	203.3512 mL
5 mM	0.8134 mL	4.0670 mL	8.1340 mL	40.6702 mL
10 mM	0.4067 mL	2.0335 mL	4.0670 mL	20.3351 mL
20 mM	0.2034 mL	1.0168 mL	2.0335 mL	10.1676 mL
50 mM	0.0813 mL	0.4067 mL	0.8134 mL	4.0670 mL
100 mM	0.0407 mL	0.2034 mL	0.4067 mL	2.0335 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc