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NIAD-4
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Catalog No. T36948Cas No. 868592-56-7
Alias NIAD4
NIAD-4 is a near-infrared (NIR) fluorescent label targeting amyloid-beta (Ki=10 nM) capable of crossing the blood-brain barrier. It serves as a fluorophore for optical imaging of Aβ in the central nervous system (CNS) for Alzheimer's disease, with absorption peaks at 475–480 nm.
NIAD-4
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Purity: 99.66%
Catalog No. T36948Alias NIAD4Cas No. 868592-56-7
NIAD-4 is a near-infrared (NIR) fluorescent label targeting amyloid-beta (Ki=10 nM) capable of crossing the blood-brain barrier. It serves as a fluorophore for optical imaging of Aβ in the central nervous system (CNS) for Alzheimer's disease, with absorption peaks at 475–480 nm.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $30 | - | In Stock | |
| 2 mg | $43 | - | In Stock | |
| 5 mg | $68 | - | In Stock | |
| 10 mg | Preferential | - | In Stock | |
| 25 mg | Preferential | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.66%
Appearance:Solid
Color:Red
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NIAD-4 is a near-infrared (NIR) fluorescent label targeting amyloid-beta (Ki=10 nM) capable of crossing the blood-brain barrier. It serves as a fluorophore for optical imaging of Aβ in the central nervous system (CNS) for Alzheimer's disease, with absorption peaks at 475–480 nm. |
| In vitro | NIAD-4 can enhance fluorescence quantum yield and fluorescence intensity by binding to amyloid aggregates and hindering their internal rotation, making it an effective tool for detecting amyloid proteins. Due to its charge neutrality and low molecular weight, NIAD-4 can penetrate the blood-brain barrier and can be used for imaging amyloid fibrils in the brain. The excitation wavelength of NIAD-4 is 475 nM, and the emission wavelength is 610 nM [2][3]. |
| Synonyms | NIAD4 |
| Molecular Weight | 334.42 |
| Formula | C18H10N2OS2 |
| Cas No. | 868592-56-7 |
| Smiles | N#CC(C#N)=CC=1SC(=CC1)C=2SC(=CC2)C=3C=CC(O)=CC3 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol: 0.2 mg/mL (0.6 mM), Sonication is recommended. DMSO: 20 mg/mL (59.81 mM), Sonication is recommended. DMSO:PBS(pH 7.2) (1:2): 0.3 mg/mL (0.9 mM), Sonication is recommended. DMF: 25 mg/mL (74.76 mM), Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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