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Candesartan-d4 (Synonyms: CV-11974 D4)

Name: Candesartan-d4
Brand: TargetMol
SKU: T10670
Price: 645 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T10670 Copy Product Info

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Candesartan-d4 is the deuterated form of Candesartan. It is an orally active Angiotensin II AT1 receptor blocker and PPAR-γ agonist with long-lasting antihypertensive effects, used as an internal standard in PK studies.

Candesartan-d4

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Catalog No. T10670

Synonyms CV-11974 D4

Cas No. 1346604-70-3

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$645	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Candesartan-d4 is the deuterated form of Candesartan. It is an orally active Angiotensin II AT1 receptor blocker and PPAR-γ agonist with long-lasting antihypertensive effects, used as an internal standard in PK studies.
Synonyms	CV-11974 D4

Chemical Properties

Molecular Weight	444.479
Formula	C₂₄H₂₀N₆O₃
Cas No.	1346604-70-3
Smiles	C(N1C=2C(N=C1OCC)=CC=CC2C(O)=O)C3=C(C(=C(C(=C3[2H])[2H])C4=C(C=CC=C4)C=5NN=NN5)[2H])[2H]
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 24.00 mg/mL (54.00 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2498 mL	11.2491 mL	22.4983 mL	112.4913 mL
5 mM	0.4500 mL	2.2498 mL	4.4997 mL	22.4983 mL
10 mM	0.2250 mL	1.1249 mL	2.2498 mL	11.2491 mL
20 mM	0.1125 mL	0.5625 mL	1.1249 mL	5.6246 mL
50 mM	0.0450 mL	0.2250 mL	0.4500 mL	2.2498 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc