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Methyl-4-oxoretinoate

Name: Methyl-4-oxoretinoate
Brand: TargetMol
SKU: T77600
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77600Cas No. 38030-58-9

Methyl-4-oxoretinoate is a synthetic retinoid compound with anticancer compounds that can induce differentiation and apoptosis in cancer cells.Methyl-4-oxoretinoate is used in the treatment of acne, psoriasis, and other skin disorders.Methyl-4-oxoretinoate has the potential to be used in the treatment of a variety of ocular disorders such as age-related macular degeneration. related macular degeneration).

Methyl-4-oxoretinoate

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Purity: 99.95%

Catalog No. T77600Cas No. 38030-58-9

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$35	-	In Stock
25 mg	$64	-	In Stock
50 mg	$98	-	In Stock
100 mg	$158	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.95%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Methyl-4-oxoretinoate AI Summary

Methyl-4-oxoretinoate has demonstrated in vivo inhibition of ornithine decarboxylase (ODC) activity induced by 12-0-tetradecanoylphorbol 13-acetate (TPA) in mouse skin, achieving an average inhibition of 18.0%. Furthermore, it has shown a 25.0% inhibition of TPA-induced ODC activity when measured by the average number of papillomas per mouse in control groups. These findings suggest that Methyl-4-oxoretinoate may have potential bioactivity in inhibiting ODC activity, which could be relevant for skin health or related conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	328.45
Formula	C₂₁H₂₈O₃
Cas No.	38030-58-9
Smiles	C(=C/C(=C/C=C/C(=C/C(OC)=O)/C)/C)\C=1C(C)(C)CCC(=O)C1C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (137.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (6.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0446 mL	15.2230 mL	30.4460 mL	152.2302 mL
5 mM	0.6089 mL	3.0446 mL	6.0892 mL	30.4460 mL
10 mM	0.3045 mL	1.5223 mL	3.0446 mL	15.2230 mL
20 mM	0.1522 mL	0.7612 mL	1.5223 mL	7.6115 mL
50 mM	0.0609 mL	0.3045 mL	0.6089 mL	3.0446 mL
100 mM	0.0304 mL	0.1522 mL	0.3045 mL	1.5223 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc