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AChE/BuChE-IN-4

Name: AChE/BuChE-IN-4
Brand: TargetMol
SKU: T77758
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77758Cas No. 1997158-25-4

AChE/BuChE-IN-4 is a multi-target AChE/BuChE inhibitor with oral activity and blood-brain barrier permeability, with IC50 values of 2.08 and 7.41 μM for AChE and BuChE, respectively.

AChE/BuChE-IN-4

🥰Excellent

Purity: 99.89%

Catalog No. T77758Cas No. 1997158-25-4

AChE/BuChE-IN-4 is a multi-target AChE/BuChE inhibitor with oral activity and blood-brain barrier permeability, with IC50 values of 2.08 and 7.41 μM for AChE and BuChE, respectively.

Pack Size	Price	Availability
1 mg	$45	In Stock
5 mg	$111	In Stock
10 mg	$167	In Stock
25 mg	$247	In Stock
50 mg	$333	In Stock
100 mg	$496	In Stock
200 mg	$671	In Stock

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Batch Information

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Purity:99.89%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description

AChE/BuChE-IN-4 is a multi-target AChE/BuChE inhibitor with oral activity and blood-brain barrier permeability, with IC50 values of 2.08 and 7.41 μM for AChE and BuChE, respectively.

Chemical Properties

Molecular Weight	297.4
Formula	C₁₇H₂₃N₅
Cas No.	1997158-25-4
Smiles	N=1C=CC(=NC1N)NCC2CCN(CC=3C=CC=CC3)CC2
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (184.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3625 mL	16.8124 mL	33.6247 mL	168.1237 mL
5 mM	0.6725 mL	3.3625 mL	6.7249 mL	33.6247 mL
10 mM	0.3362 mL	1.6812 mL	3.3625 mL	16.8124 mL
20 mM	0.1681 mL	0.8406 mL	1.6812 mL	8.4062 mL
50 mM	0.0672 mL	0.3362 mL	0.6725 mL	3.3625 mL
100 mM	0.0336 mL	0.1681 mL	0.3362 mL	1.6812 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc