ga

GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively. This compound simultaneously acts as an activator of cell proliferation by promoting YAP/TAZ activation and their nuclear translocation. Additionally, GA-017 enhances cell growth in 3D culture conditions and augments the ex vivo formation of mouse intestinal organoids [1].

17-AEP-GA is an HSP90 antagonist, a potent inhibitor of glioblastoma cell proliferation, survival, migration, and invasion, and a toxic component of antibody-coupled activated molecules (ADCs), which can be used to study glioblastomas.

Duocarmycin GA, an antibody drug conjugate (ADC) toxin and a DNA alkylating agent, effectively targets and binds in the minor groove of DNA. It is particularly potent against multi-drug resistant cell lines, offering a strategic approach in combating resistance.

GA3-AM is a cell-permeable chemical dimerizer.

17-DMAP-GA, a Geldanamycin analogue, acts as an HSP90 inhibitor, leading to cell cycle abnormalities.

Ga(III)protoporphyrin-IX, a model for interporphyrin interactions in malaria pigment, possesses potent antibacterial effects against gram-negative, gram-positive, and acid-fast bacteria. It exhibits high solubility in methanol (MeOH) and serves as a malarial pigment analogue for drug development, as well as a potential antibacterial agent.

17-GMB-APA-GA, a potent HSP90 inhibitor, is an ADC cytotoxin commonly employed for studying latent T. gondii infection.

p-NCS-Bz-DOTA-GA is a bifunctional chelating agent.

p-NCS-Bz-NODA-GA is a bifunctional chelating agent.

1. Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive. 2. Octyl Gallate has antimetastatic activity. 3. Octyl Gallate shows antimicrobial activity against H. pylori, with a minimum inhibitory concentration (MIC) value of 125 ug/mL. 4. Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease.5. Octyl Gallate is a potential anticancer agent, it exhibited decreased MCF-7 & MDA-MB-231 survival and induced apoptosis, with IC50 value of 40 uM. 6. Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) has antiviral activity, it shows an inhibitory effect on the growth of herpes simplex virus type 1 (HSV-1) in HEp-2 or Vero cells. 7. Octyl gallate shows antifungal activity against Saccharomyces cerevisiae ATCC7754 and Zygosaccharomyces bailii ATCC 60483.

JHU395 is an orally-bioavailable prodrug of a lipophilic glutamine antagonist (GA), 6-diazo-5-oxo-L-norleucine (DON). It demonstrates delivery of DON to malignant peripheral nerve sheath tumor (MPNST) both in vitro and in vivo, resulting in significant antitumor activity in MPNST. Additionally, JHU395 exhibits plasma stability.

Gibberellic acid (GA3) is a hormone found in plants and fungi.

Olaflur is a compound that prevents dental caries.

Obinutuzumab (Obinutuzumab/afutuzumab) GA101) is a glycoengineered Type II CD20 monoclonal antibody in development for non-Hodgkin lymphoma.

18:1 Glutaryl PE monosodium is a functionalized lipid.

GA 0113 is an effective orally active antagonist of the angiotensin II (Ang II) AT1 receptor. It inhibits the hypertensive response induced by Ang II, with an ID50 of 0.032 mg/kg, and dose-dependently increases plasma renin activity for up to 48 hours.

Pro-GA is a cell-permeable γ-glutamylcyclotransferase (γ-GGCT) inhibitor that exhibits dose-dependent inhibition of proliferation in multiple bladder cancer cell lines. It demonstrates antitumour activity with an IC50 of 57 μM against T24 cells.

GA-O-02, an 18β-Glycyrrhetinic acid (GA) derivative, functions as a powerful antimicrobial and anti-inflammatory agent. This compound inhibits NO, pro-inflammatory cytokines, and chemokines to exert its anti-inflammatory effects. Additionally, GA-O-02 demonstrates significant antimicrobial activity against Gram-positive bacteria.

GA-O-06, an 18β-Glycyrrhetinic acid derivative, serves as a potent antimicrobial and anti-inflammatory agent. It achieves its anti-inflammatory effects by inhibiting NO, pro-inflammatory cytokines, and chemokines, while demonstrating significant antimicrobial activity against Gram-positive bacteria.

DOPE-GA is a chemical compound utilized in the formulation of liposomes for drug delivery research [1].

SNNF(N-Me)GA(N-Me)ILSS is a biologically active peptide containing double N-methylated derivatives of an amyloidogenic and cytotoxic partial IAPP sequence.

SNNF(N-Me)GA(N-Me)IL is a biologically active peptide featuring double N-methylated derivatives of a partial IAPP sequence, known for its amyloidogenic and cytotoxic properties.

NF(N-Me)GA(N-Me)IL is a biologically active peptide, representing a modified segment (amino acids 22 to 27) of the human islet amyloid polypeptide (hIAPP) sequence NFGAIL. This modification includes N-methylations at G24 and I26, transforming the amyloidogenic and cytotoxic nature of the original sequence into a non-amyloidogenic and non-cytotoxic variant. Moreover, the peptide maintains the ability to bind with high affinity to full-length hIAPP, effectively inhibiting its fibril formation.

F(N-Me)GA(N-Me)IL is a bioactive peptide derived from a partial IAPP sequence that contains double N-methylations. These modifications prevent the peptide from forming β-sheet structures and exhibiting amyloidogenicity or cytotoxicity. Additionally, the derivatives can interact with native sequences to inhibit amyloid formation.