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CotH3 peptide

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Catalog No. TP3806

The CotH3 peptide is a functional peptide unique to mucormyetes that can bind to the host GRP78 receptor, facilitating entry into endothelial cells. Monoclonal antibodies produced against the CotH3 peptide can protect immunocompromised mice from mucormycosis caused by Rhizopus delemar (R. delemar) and other mucormyetes. Additionally, the CotH3 peptide works synergistically with antifungal drugs to protect diabetic ketoacidosis (DKA) mice from R. delemar infections.

CotH3 peptide

CotH3 peptide

😃Good
Catalog No. TP3806
The CotH3 peptide is a functional peptide unique to mucormyetes that can bind to the host GRP78 receptor, facilitating entry into endothelial cells. Monoclonal antibodies produced against the CotH3 peptide can protect immunocompromised mice from mucormycosis caused by Rhizopus delemar (R. delemar) and other mucormyetes. Additionally, the CotH3 peptide works synergistically with antifungal drugs to protect diabetic ketoacidosis (DKA) mice from R. delemar infections.
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
The CotH3 peptide is a functional peptide unique to mucormyetes that can bind to the host GRP78 receptor, facilitating entry into endothelial cells. Monoclonal antibodies produced against the CotH3 peptide can protect immunocompromised mice from mucormycosis caused by Rhizopus delemar (R. delemar) and other mucormyetes. Additionally, the CotH3 peptide works synergistically with antifungal drugs to protect diabetic ketoacidosis (DKA) mice from R. delemar infections.
Chemical Properties
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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