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E3 ligase Ligand 24

Name: E3 ligase Ligand 24
Brand: TargetMol
SKU: T209670
Rating: 4.5 (1 reviews)

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Catalog No. T209670Cas No. 3038773-47-3

E3ligaseLigand 24 (Compound 24) is a potent ligand for the E3 ligase DCAF15 with an IC50 of 0.053 μM. Due to its selectivity and strong binding properties, E3ligaseLigand 24 plays a crucial role in research focused on targeted protein degradation.

E3 ligase Ligand 24

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Catalog No. T209670Cas No. 3038773-47-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	E3ligaseLigand 24 (Compound 24) is a potent ligand for the E3 ligase DCAF15 with an IC50 of 0.053 μM. Due to its selectivity and strong binding properties, E3ligaseLigand 24 plays a crucial role in research focused on targeted protein degradation.
In vitro	E3 ligase Ligand 24, when applied at 5μM for 24 hours, effectively degrades BRD4 protein in HEK293 cells tagged with HiBiT, and this degradation occurs independently of DCAF15 mediation.

Chemical Properties

Molecular Weight	513.39
Formula	C₂₁H₂₂Cl₂N₄O₅S
Cas No.	3038773-47-3
Smiles	O=C(C=1OC(=CC1C)S(=O)(=O)NC2=CC=C(Cl)C=3C(Cl)=CNC23)N4CCC(C(=O)NC)CC4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc