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ATPγS tetralithium salt

Name: ATPγS tetralithium salt
Brand: TargetMol
SKU: T22592
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22592Cas No. 93839-89-5

Alias ATP-gamma-S tetralithium salt

ATPγS tetralithium salt is a good substrate for RNA-stimulated nucleotide hydrolysis and RNA unwinding activity of eIF4A.

ATPγS tetralithium salt

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Purity: 95%

Catalog No. T22592Alias ATP-gamma-S tetralithium saltCas No. 93839-89-5

ATPγS tetralithium salt is a good substrate for RNA-stimulated nucleotide hydrolysis and RNA unwinding activity of eIF4A.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$67	In Stock	In Stock
5 mg	$161	In Stock	In Stock
10 mg	$278	In Stock	In Stock
25 mg	$593	In Stock	In Stock
50 mg	$1,020	In Stock	In Stock
100 mg	$1,770	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:95%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR PNMR

Product Introduction

Bioactivity

Description	ATPγS tetralithium salt is a good substrate for RNA-stimulated nucleotide hydrolysis and RNA unwinding activity of eIF4A.
In vitro	ATPγS tetralithium salt enhances intrinsic fluorescence and induces aggregation, thereby increasing spinach Rubisco activating enzyme activity. The concentration dependence of the ATPγS tetralithium salt effect is S-shaped, but at pH 8, the half-saturation requirement of ATPγS tetralithium salt (12 μM) is consistent with that measured indirectly using the fluorescent probe 1-anilinolyl-8-sulfonate. The binding affinities (6 μM) are not much different. [2]
In vivo	METHODS: A mouse model of ALI induced by intratracheal administration of endotoxin/lipopolysaccharide (LPS) and cultured lung ECs was used and treated with ATPγS tetralithium salt (50-100 μM final blood concentration). RESULTS ATPγS tetralithium salt attenuated the inflammatory response, reduced the accumulation of cells (48%, P < 0.01) and proteins (57%, P < 0.01) in bronchoalveolar lavage fluid, and reduced neutrophil infiltration and Evans blue albumin dye extravasation into lung tissue. [3]
Synonyms	ATP-gamma-S tetralithium salt

Chemical Properties

Molecular Weight	546.98
Formula	C₁₀H₁₂Li₄N₅O₁₂P₃S
Cas No.	93839-89-5
Smiles	O[C@H]1[C@@H](O[C@@H]([C@H]1O)COP(OP(OP([O-])([S-])=O)([O-])=O)([O-])=O)N2C3=NC=NC(N)=C3N=C2.[Li+].[Li+].[Li+].[Li+]
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 25 mg/mL (45.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.66 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.8282 mL	9.1411 mL	18.2822 mL	91.4110 mL
5 mM	0.3656 mL	1.8282 mL	3.6564 mL	18.2822 mL
10 mM	0.1828 mL	0.9141 mL	1.8282 mL	9.1411 mL
20 mM	0.0914 mL	0.4571 mL	0.9141 mL	4.5706 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc