ω-Conotoxin GVIA

Name: ω-Conotoxin GVIA
Brand: TargetMol
SKU: TP2062
Rating: 4.5 (1 reviews)

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Catalog No. TP2062Cas No. 106375-28-4

Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.

ω-Conotoxin GVIA

😃Good

Catalog No. TP2062Cas No. 106375-28-4

Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.

Pack Size	Price	Availability	Quantity
250 μg	$1,680	35 days

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Product Introduction

Bioactivity

Description

Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.

Chemical Properties

Molecular Weight	3037
Formula	C₁₂₀H₁₈₂N₃₈O₄₃S₆
Cas No.	106375-28-4
Relative Density.	1.71 g/cm3
Sequence	Cys-Lys-Ser-{Hyp}-Gly-Ser-Ser-Cys-Ser-{Hyp}-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-{Hyp}-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 (Disulfide bridge: Cys1-Cys16; Cys8-Cys19; Cys15-Cys26)
Sequence Short	CKS-{Hyp}-GSSCS-{Hyp}-TSYNCCRSCN-{Hyp}-YTKRCY-NH2 (Disulfide bridge: Cys1-Cys16; Cys8-Cys19; Cys15-Cys26)

Storage & Solubility Information

Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	H2O: 1 mg/mL (0.33 mM), Sonication is recommended.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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