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E3 ligase Ligand-Linker Conjugate 46
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Catalog No. T209481
E3ligaseLigand-Linker Conjugate 46 is a conjugate consisting of an E3 ligase ligand linked to a linker (E3LigaseLigand-Linker Conjugates), composed of (S,R,S)-AHPC and its corresponding linker. The (S,R,S)-AHPC is a von Hippel-Lindau (VHL) ligand based on VH032, capable of recruiting the VHL protein. E3ligaseLigand-Linker Conjugate 46 serves as a crucial intermediate for synthesizing complete PROTAC molecules.
E3 ligase Ligand-Linker Conjugate 46
E3 ligase Ligand-Linker Conjugate 46
🥰Excellent
Catalog No. T209481
E3ligaseLigand-Linker Conjugate 46 is a conjugate consisting of an E3 ligase ligand linked to a linker (E3LigaseLigand-Linker Conjugates), composed of (S,R,S)-AHPC and its corresponding linker. The (S,R,S)-AHPC is a von Hippel-Lindau (VHL) ligand based on VH032, capable of recruiting the VHL protein. E3ligaseLigand-Linker Conjugate 46 serves as a crucial intermediate for synthesizing complete PROTAC molecules.
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| Description | E3ligaseLigand-Linker Conjugate 46 is a conjugate consisting of an E3 ligase ligand linked to a linker (E3LigaseLigand-Linker Conjugates), composed of (S,R,S)-AHPC and its corresponding linker. The (S,R,S)-AHPC is a von Hippel-Lindau (VHL) ligand based on VH032, capable of recruiting the VHL protein. E3ligaseLigand-Linker Conjugate 46 serves as a crucial intermediate for synthesizing complete PROTAC molecules. |
| Formula | C40H60N6O8S |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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