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Swinholide A

Catalog No. T35782 CAS 95927-67-6

Synonyms: MK-7684

Swinholide A is a polyketone compound that can be extracted from sponges and binds to actin to dimerize actin with Kd of about 50 nM. Swinholide A is a cytotoxin that stabilizes actin dimers and severs actin filaments. Swinholide A has antifungal activity and can damage the actin cytoskeleton of cells.

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Swinholide A, CAS 95927-67-6

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10 μg	35 days	$ 290.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

First isolated from the Okinawan marine sponge Theonella swinhoei, Swinholide A dimerizes actin[1].
Isolated from the marine sponge Theonella swinhoei, Swinholide A is highly cytotoxic to a variety of cancer cell lines[2].
Disrupting the actin cytoskeleton of cells grown in culture, Swinholide A sequesters actin dimers in vitro in both polymerizing and non-polymerizing buffers, with a binding stoichiometry of one Swinholide A molecule per actin dimer. Additionally, it rapidly severs F-actin in vitro with high cooperativity[2].

Synonyms	MK-7684
Molecular Weight	1389.87
Formula	C78H132O20
CAS No.	95927-67-6

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Methanol: Soluble

DMSO: Soluble

Ethanol: Soluble

References and Literature

1. Inji Shin,et al. Total Synthesis of Swinholide A: An Exposition in Hydrogen-Mediated C-C Bond Formation. J Am Chem Soc. 2016 Nov 2;138(43):14246-14249. 2. M R Bubb, et al. Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. J Biol Chem. 1995 Feb 24;270(8):3463-6. 3. Terry, D.R., Higa, T., and Bubb, M.R. Misakinolide A is a marine macrolide that caps but does not sever filamentous actin. The Journal of Biological Chemisty 272(12), 7841-7845 (1997)

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Keywords

Swinholide A 95927-67-6 Microbiology/Virology Antifungal MK-7684 MK 7684 MK7684 inhibitor inhibit

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