Swinholide A

Name: Swinholide A
Brand: TargetMol
SKU: T35782
Price: 290 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35782Cas No. 95927-67-6

Alias MK-7684

Swinholide A is a polyketone compound that can be extracted from sponges and binds to actin to dimerize actin with Kd of about 50 nM. Swinholide A is a cytotoxin that stabilizes actin dimers and severs actin filaments. Swinholide A has antifungal activity and can damage the actin cytoskeleton of cells.

Swinholide A

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Catalog No. T35782Alias MK-7684Cas No. 95927-67-6

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10 μg	$290	-	In Stock

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Bioactivity

Description	Swinholide A is a polyketone compound that can be extracted from sponges and binds to actin to dimerize actin with Kd of about 50 nM. Swinholide A is a cytotoxin that stabilizes actin dimers and severs actin filaments. Swinholide A has antifungal activity and can damage the actin cytoskeleton of cells.
In vitro	First isolated from the Okinawan marine sponge Theonella swinhoei, Swinholide A dimerizes actin[1]. Isolated from the marine sponge Theonella swinhoei, Swinholide A is highly cytotoxic to a variety of cancer cell lines[2]. Disrupting the actin cytoskeleton of cells grown in culture, Swinholide A sequesters actin dimers in vitro in both polymerizing and non-polymerizing buffers, with a binding stoichiometry of one Swinholide A molecule per actin dimer. Additionally, it rapidly severs F-actin in vitro with high cooperativity[2].
Synonyms	MK-7684

Chemical Properties

Molecular Weight	1389.87
Formula	C₇₈H₁₃₂O₂₀
Cas No.	95927-67-6
Smiles	[H][C@]12CC=C[C@@]([H])(C[C@@H](O)CC=C(C)C=CC(=O)O[C@]([H])([C@@H](C)[C@@H](O)[C@@H](C)CC[C@H]3C[C@@H](C[C@H](C)O3)OC)[C@@H](C)[C@H](O)C[C@H](O)[C@H](C)[C@H](C[C@]3([H])CC=C[C@@]([H])(C[C@@H](O)CC=C(C)C=CC(=O)O[C@]([H])([C@@H](C)[C@@H](O)[C@@H](C)CC[C@H]4C[C@@H](C[C@H](C)O4)OC)[C@@H](C)[C@H](O)C[C@H](O)[C@H](C)[C@H](C1)OC)O3)OC)O2 \|c:3,53\|
Relative Density.	1.15 g/cm3 (Predicted)

Storage & Solubility Information

Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	Methanol: Soluble DMSO: Soluble Ethanol: Soluble

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10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

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Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

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