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Trequinsin hydrochloride

Name: Trequinsin hydrochloride
Brand: TargetMol
SKU: T23476
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23476Cas No. 78416-81-6

Alias HL 725

Trequinsin hydrochloride (HL 725) is a potent phosphodiesterase (PDE) inhibitor and inhibitor of platelet aggregation, and is a novel antihypertensive vasodilator for the study of cardiovascular disease.

Trequinsin hydrochloride

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Purity: 99.95%

Catalog No. T23476Alias HL 725Cas No. 78416-81-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.95%

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COA

Product Introduction

Bioactivity

Description	Trequinsin hydrochloride (HL 725) is a potent phosphodiesterase (PDE) inhibitor and inhibitor of platelet aggregation, and is a novel antihypertensive vasodilator for the study of cardiovascular disease.
Targets&IC50	platelet cAMP phosphodiesterase (PDE):0.25 nM
In vitro	In addition to its cardioprotective and antihypertensive effects, Trequinsin hydrochloride exhibits significant antiplatelet activity.Trequinsin hydrochloride is a potent inhibitor of platelet cAMP phosphodiesterase (PDE) with an IC50 of 0.25 nM. [1] In addition, Trequinsin hydrochloride is a potent calcium agonist. [3]
Synonyms	HL 725

Chemical Properties

Molecular Weight	441.95
Formula	C₂₄H₂₈ClN₃O₃
Cas No.	78416-81-6
Smiles	Cl.O=C1N(C(=NC=2C(=CC(=CC2C)C)C)C=C3C=4C=C(OC)C(OC)=CC4CCN13)C
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40 mg/mL (90.51 mM), Sonication is recommended.

DMSO: 50 mg/mL (113.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2627 mL	11.3135 mL	22.6270 mL	113.1350 mL
5 mM	0.4525 mL	2.2627 mL	4.5254 mL	22.6270 mL
10 mM	0.2263 mL	1.1313 mL	2.2627 mL	11.3135 mL
20 mM	0.1131 mL	0.5657 mL	1.1313 mL	5.6567 mL
50 mM	0.0453 mL	0.2263 mL	0.4525 mL	2.2627 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0226 mL	0.1131 mL	0.2263 mL	1.1313 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc