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PSMA-DIM

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Catalog No. T211832

PSMA-DIM is a dimeric PSMA ligand with a Kd value of 37.09 nM for LNCaP cells. It can be radiolabeled with [68Ga]Ga to form [68Ga]Ga-PSMA-DIM, which effectively differentiates cells and animal models with varying PSMA expression levels. [68Ga]Ga-PSMA-DIM exhibits high uptake in LNCaP cells and maximizes tumor uptake. PSMA-DIM is applicable in prostate cancer (PCa) research.

PSMA-DIM

PSMA-DIM

😃Good
Catalog No. T211832
PSMA-DIM is a dimeric PSMA ligand with a Kd value of 37.09 nM for LNCaP cells. It can be radiolabeled with [68Ga]Ga to form [68Ga]Ga-PSMA-DIM, which effectively differentiates cells and animal models with varying PSMA expression levels. [68Ga]Ga-PSMA-DIM exhibits high uptake in LNCaP cells and maximizes tumor uptake. PSMA-DIM is applicable in prostate cancer (PCa) research.
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Product Introduction

Bioactivity
Description
PSMA-DIM is a dimeric PSMA ligand with a Kd value of 37.09 nM for LNCaP cells. It can be radiolabeled with [68Ga]Ga to form [68Ga]Ga-PSMA-DIM, which effectively differentiates cells and animal models with varying PSMA expression levels. [68Ga]Ga-PSMA-DIM exhibits high uptake in LNCaP cells and maximizes tumor uptake. PSMA-DIM is applicable in prostate cancer (PCa) research.
In vitro
[68 Ga]Ga-PSMA-DIM (1.58 nM, 15-120 min) demonstrates superior endocytosis in LNCaP cells compared to 22Rv1 and PC-3 cells, with its efficacy being contingent on the expression level of PSMA.
In vivo
Administered intravenously in a dose of 5.55 MBq, [^68Ga]Ga-PSMA-DIM demonstrated significant uptake in PSMA-positive LNCaP and 22Rv1 mouse tumors, while exhibiting minimal accumulation in PC-3 tumors.
Chemical Properties
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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