r 1

Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.

Zingibroside R1 (Ginsenoside Z-R1) has anti-HIV-1 activity.

Suavissimoside R1 is a natural product isolated from Rubus parvifolius, suitable for biochemical experiments and drug synthesis research.

R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.

R1-11 is an indole-based ICMT inhibitor with an IC50 of 0.6 μM, exhibiting anticancer properties. It inhibits MDA-MB231 and PC3 cells with IC50 values of 2.2 μM and 2.0 μM, respectively.

Anti-MouseIL-12Antibody (R1-5D9) is an IgG2a antibody inhibitor derived from rats, designed to target and inhibit mouse IL-12.

Anti-Fc gamma R1 Antibody is a humanized monoclonal antibody that targets Fc gamma RI (CD64) and can be used in immunological research.

Zingibroside R1 (Standard) is a reference standard for research and analysis in studies involving Zingibroside R1. Zingibroside R1 (Ginsenoside Z-R1) has anti-HIV-1 activity.

Notoginsenoside R1 (Standard) is a reference standard for research and analysis in studies involving Notoginsenoside R1. Notoginsenoside R1 (Sanchinoside R1) belongs to the saponin class of natural products, and is the main active monomer of Panax ginseng. Notoginsenoside R1 has cardiovascular, neuroprotective, hepatoprotective, antitumor and immunomodulatory activities.

(R)-WRN inhibitor 1 is the R-isomer of WRN inhibitor 1 (example 7). It functions as a WRN inhibitor with anticancer properties.

Saniculoside R 1 is a new triterpenoid saponin from Sanicula europaea.

5-HT6R/FAAH modulator 1 is a selective ligand for the serotonin 5-HT6 receptor and an inhibitor of the fatty acid amide hydrolase (FAAH). It exhibits a pKi of 6.33 for 5-HT6 and a pIC50 of 6.33 for FAAH. This compound also shows mild inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with a pIC50 of 5.12. Additionally, it can inhibit apoptosis and reduce reactive oxygen species (ROS) levels. 5-HT6R/FAAH modulator 1 is applicable in the study of neurological disorders such as Alzheimer's disease (AD).

CB1R Allosteric Modulator 1 (compound 11) is a potent allosteric modulator of CB1Rs, negatively affecting the functional activity of orthosteric ligands [NAM] at CB1Rs.

5-HT6R/MAO-B modulator 1 is an antagonist of 5-HT6R (at Gs signaling) and an irreversible inhibitor of MAO-B that exhibits glial protective activity and induces scopolamine-induced memory deficits.

KRas G12R Inhibitor 1 (compound 3) is a selective covalent inhibitor targeting the KRas G12R mutation, leveraging the high nucleophilicity of mutant cysteines to bind irreversibly within the K-Ras Switch II region. This compound is utilized in cancer research [1].

KRAS G12C inhibitor 1R can be used in studies about Ras.

Compound 38-S is an orally active CB1R/AMPK modulator with a K i of 0.81 nM and an IC50 of 3.9 nM for CB1R. This compound activates AMPK and has been shown to decrease food intake and body weight, in addition to enhancing glucose tolerance and insulin sensitivity [1].

IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.

IDH2R140Q-IN-2 is an orally active and potent IDH2R140Q inhibitor with an IC50 of 29 nM.IDH2R140Q-IN-2 possesses potential antitumour activity, reducing D2HG production in TF-1 cell lines carrying the IDH2R140Q mutation (IC50 of 10 nM) and inhibiting tumour tissue D2HG levels.IDH2R140Q-IN-2 is suitable for the study of acute myeloid leukaemia (AML).

(R)-1-Boc-3-(hyroxymethyl)piperidine ,with CAS No. 140695-85-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (R)-1-Boc-3-(hyroxymethyl)piperidine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(+)-cis-2-Benzylaminocyclohexanemethanol ,with CAS No. 71581-92-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (+)-cis-2-Benzylaminocyclohexanemethanol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(R)-2-amino-3-benzyloxy-1-propanol ,with CAS No. 58577-87-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (R)-2-amino-3-benzyloxy-1-propanol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(1R,3s)-4-cyclopentene-1,3-diol 1-acetate ,with CAS No. 60410-16-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (1R,3s)-4-cyclopentene-1,3-diol 1-acetate provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

rac-(1R,2S)-2-hydroxycyclohexane-1-carbonitrile ,with CAS No. 63301-31-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. rac-(1R,2S)-2-hydroxycyclohexane-1-carbonitrile provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.