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Poloxamer 124 (L44)
(Synonyms: Poloxamer 124 (L44)) Copy Product Info
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Synonyms: Poloxamer 124 (L44)
Catalog No. TSH-00515 Copy Product Info
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Poloxamer 124 (L44) is a block copolymer of polyoxyethylene and polyoxypropylene with an average molecular weight of 2200. Poloxamer 124 (L44) exhibits oral toxicity in albino rat studies with an LD50 of 5 g/kg and causes eye irritation. Poloxamer 124 (L44) forms thermoreversible hydrogels and is used in pharmaceutical formulation research and biomaterials studies investigating surfactant-mediated drug solubilization, hydrogel phase transition behavior, and polymer-based delivery systems in biological environments.
Poloxamer 124
(L44)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 g | $49 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Color:White
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| Description | Poloxamer 124 (L44) is a block copolymer of polyoxyethylene and polyoxypropylene with an average molecular weight of 2200. Poloxamer 124 (L44) exhibits oral toxicity in albino rat studies with an LD50 of 5 g/kg and causes eye irritation. Poloxamer 124 (L44) forms thermoreversible hydrogels and is used in pharmaceutical formulation research and biomaterials studies investigating surfactant-mediated drug solubilization, hydrogel phase transition behavior, and polymer-based delivery systems in biological environments. |
| In vivo | Methods:Rats were intragastrically administered with 0.17 mg/mL Poloxamer 124 (L44) at a rate of 3 mL/h for 1 hour. Lipid transport in the lymphatic system and lipid recovery rate in the intestinal lumen were determined. Results:Poloxamer 124 (L44) markedly reduced the transport of triglycerides and cholesterol as well as phospholipid output in the rat lymphatic system, while exerting no obvious impact on digestive and absorptive functions. The recovery rates of intestinal lumen lipids and cholesterol remained unchanged [3]. It suggests that Poloxamer 124 (L44) can interfere with lipoprotein assembly and/or the efflux of lipoproteins from intestinal mucosal cells. |
| Synonyms | Poloxamer 124 (L44) |
| Molecular Weight | 2200 (Average) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: 160 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Poloxamer 124 (L44) in vivo | Poloxamer 124 (L44) molecular weight
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