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SR10098
Catalog No. T83644 Copy Product Info
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SR10098 is a high-affinity ligand for the NR4A nuclear receptor family that exhibits significant activating activity toward Nurr1 (NR4A2) (EC₅₀ = 24 nM) and modulatory effects on other members of the NR4A family (Nur77, Nor1). Nurr1 is involved in regulating the development, survival, and maintenance of dopaminergic neurons. Therefore, SR10098 can be used in research on Parkinson’s disease (PD) and neurodegenerative disorders.
SR10098
Copy Product Info🥰Excellent
Catalog No. T83644
SR10098 is a high-affinity ligand for the NR4A nuclear receptor family that exhibits significant activating activity toward Nurr1 (NR4A2) (EC₅₀ = 24 nM) and modulatory effects on other members of the NR4A family (Nur77, Nor1). Nurr1 is involved in regulating the development, survival, and maintenance of dopaminergic neurons. Therefore, SR10098 can be used in research on Parkinson’s disease (PD) and neurodegenerative disorders.
Cas No. 850705-30-5
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | - | In Stock | |
| 5 mg | $483 | - | In Stock | |
| 10 mg | $691 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,490 | - | In Stock | |
| 100 mg | $1,960 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Appearance:Solid
Color:Yellow
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| Description | SR10098 is a high-affinity ligand for the NR4A nuclear receptor family that exhibits significant activating activity toward Nurr1 (NR4A2) (EC₅₀ = 24 nM) and modulatory effects on other members of the NR4A family (Nur77, Nor1). Nurr1 is involved in regulating the development, survival, and maintenance of dopaminergic neurons. Therefore, SR10098 can be used in research on Parkinson’s disease (PD) and neurodegenerative disorders. |
| In vitro | Methods: HEK293T, PC12, and SK-N-BE(2)-C cells (transfected with Gal4-VP16 expression plasmids and UAS-luc reporter plasmids) were treated with SR10098 (0.16–100 μM) for 18 hours, and the fluorescence intensity of the luciferase reporter gene was measured. Results: SR10098 activated the Gal4-VP16 reporter gene in SK-N-BE(2)-C cells, with an intensity approximately twice that of the control group. [1] |
| Molecular Weight | 256.23 |
| Formula | C14H9FN2O2 |
| Cas No. | 850705-30-5 |
| Smiles | O=C(O)C1=CC=C2N=C(NC2=C1)C=3C=CC(F)=CC3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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