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Quisqualic acid

Name: Quisqualic acid
Brand: TargetMol
SKU: T67761
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: L-Quisqualic acid) Copy Product Info

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Synonyms: L-Quisqualic acid

Catalog No. T67761 Copy Product Info

Purity: 99.91%

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Quisqualic acid is an agonist of the AMPA, kainate, and group I metabotropic glutamate receptors. Quisqualic acid is among the most potent AMPA receptor agonists currently characterized. Quisqualic acid induces excitotoxicity and is widely utilized in neuroscience research to selectively destroy neurons in the brain or spinal cord. Quisqualic acid occurs naturally in the seeds of Quisqualis species. Quisqualic acid is particularly valuable for investigations involving glutamatergic neurotransmission, receptor pharmacology, excitotoxic neuronal injury, and neural circuit mapping.

Cas No. 52809-07-1

Pack Size	Price	USA Stock	Global Stock
1 mg	$44	-	In Stock
5 mg	$128	-	In Stock
1 mL x 10 mM (in DMSO)	$135	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.91%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Quisqualic acid is an agonist of the AMPA, kainate, and group I metabotropic glutamate receptors. Quisqualic acid is among the most potent AMPA receptor agonists currently characterized. Quisqualic acid induces excitotoxicity and is widely utilized in neuroscience research to selectively destroy neurons in the brain or spinal cord. Quisqualic acid occurs naturally in the seeds of Quisqualis species. Quisqualic acid is particularly valuable for investigations involving glutamatergic neurotransmission, receptor pharmacology, excitotoxic neuronal injury, and neural circuit mapping.
Targets & IC50	mGluR4:593 μM, mGluR1:45 nM (EC50), mGluR2:108 μM, mGluR4:112 μM (Ki), mGluR2:113 μM (Ki), mGluR1:10 nM (Ki)
In vitro	Quisqualic acid activates mGlu1R (EC50=0.045 μM; Ki=0.01 μM) and mGlu2R (EC50=108 μM; Ki=113 μM)[1].
Synonyms	L-Quisqualic acid

Chemical Properties

Molecular Weight	189.13
Formula	C₅H₇N₃O₅
Cas No.	52809-07-1
Smiles	C([C@@H](C(O)=O)N)N1C(=O)NC(=O)O1
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from direct sunlight,Keep away from moisture,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (52.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2874 mL	26.4368 mL	52.8737 mL	264.3684 mL
5 mM	1.0575 mL	5.2874 mL	10.5747 mL	52.8737 mL
10 mM	0.5287 mL	2.6437 mL	5.2874 mL	26.4368 mL
20 mM	0.2644 mL	1.3218 mL	2.6437 mL	13.2184 mL
50 mM	0.1057 mL	0.5287 mL	1.0575 mL	5.2874 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: Quisqualic acid chemical structure | Quisqualic acid in vitro | Quisqualic acid formula | Quisqualic acid molecular weight