Shopping Cart

Your shopping cart is currently empty

GYKI 53655 hydrochloride

Name: GYKI 53655 hydrochloride
Brand: TargetMol
SKU: T15456
Price: 49 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T15456Cas No. 143692-48-2

Alias LY300168 hydrochloride, GYKI53655 hydrochloride

GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.

GYKI 53655 hydrochloride

Copy Product Info

😃Good

Purity: 98.02%

Catalog No. T15456Alias LY300168 hydrochloride, GYKI53655 hydrochlorideCas No. 143692-48-2

GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$49	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.02%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS

Product Introduction

Bioactivity

Description	GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.
Targets&IC50	mGluR1:6 μM, mGluR4:5 μM
In vitro	GYKI 53655 hydrochloride inhibited AMPA (10 μM)-mediated responses in recombinant human GluR1 receptors expressed in HEK293 cells and recombinant human GluR4 receptors expressed in HEK293 cells with approximate IC50 values of 6 μM and 5 μM, respectively.[1].
In vivo	GYKI 53655 hydrochloride (2-8 mg/kg) can dose-dependently inhibit or completely abolish AMPA responses in vivo[3].
Synonyms	LY300168 hydrochloride, GYKI53655 hydrochloride

Chemical Properties

Molecular Weight	388.85
Formula	C₁₉H₂₁ClN₄O₃
Cas No.	143692-48-2
Smiles	Cl.CNC(=O)N1N=C(c2ccc(N)cc2)c2cc3OCOc3cc2CC1C
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (308.6 mM), Sonication is recommended.

H2O: 2 mg/mL (5.14 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5717 mL	12.8584 mL	25.7169 mL	128.5843 mL
5 mM	0.5143 mL	2.5717 mL	5.1434 mL	25.7169 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2572 mL	1.2858 mL	2.5717 mL	12.8584 mL
20 mM	0.1286 mL	0.6429 mL	1.2858 mL	6.4292 mL
50 mM	0.0514 mL	0.2572 mL	0.5143 mL	2.5717 mL
100 mM	0.0257 mL	0.1286 mL	0.2572 mL	1.2858 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc