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IDOR-1104-0086
Catalog No. T213131 Copy Product Info
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IDOR-1104-0086 is an orally active Kv7 potassium channel opener capable of crossing the blood-brain barrier, with an EC50 of 210 nM. It demonstrates strong selectivity for the hERG channel, with an IC20 of 25 μM. IDOR-1104-0086 exhibits efficacy and good tolerability in two rodent epilepsy models and can be utilized in epilepsy studies.
IDOR-1104-0086
Copy Product Info🥰Excellent
Catalog No. T213131
IDOR-1104-0086 is an orally active Kv7 potassium channel opener capable of crossing the blood-brain barrier, with an EC50 of 210 nM. It demonstrates strong selectivity for the hERG channel, with an IC20 of 25 μM. IDOR-1104-0086 exhibits efficacy and good tolerability in two rodent epilepsy models and can be utilized in epilepsy studies.
IDOR-1104-0086
Cas No. 2756581-81-2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | IDOR-1104-0086 is an orally active Kv7 potassium channel opener capable of crossing the blood-brain barrier, with an EC50 of 210 nM. It demonstrates strong selectivity for the hERG channel, with an IC20 of 25 μM. IDOR-1104-0086 exhibits efficacy and good tolerability in two rodent epilepsy models and can be utilized in epilepsy studies. |
| Targets&IC50 | Kv7 channel:250 nM (EC50) |
| In vitro | IDOR-1104-0086 (Compound 31) effectively inhibits pathological calcium oscillations in a primary rat cortical neuron-astrocyte co-culture system, with an IC50 of 188 nM (acute) and 228 nM (20 minutes). |
| In vivo | IDOR-1104-0086 (Compound 31) (10-30 mg/kg, oral, single dose) effectively permeates rodent brain tissue, achieving a brain-to-plasma unbound ratio ([B/P] u) greater than 127% one hour post-administration. It nearly completely inhibits generalized tonic-clonic seizures in AGS mouse models and results in a dose-dependent reduction of seizure intensity in the rat kindling model. |
| Molecular Weight | 334.29 |
| Formula | C15H15F5N2O |
| Cas No. | 2756581-81-2 |
| Smiles | O=C(NCC1=CC=CC(=C1)C(F)(F)F)NC23CC(C2)(C3)C(F)F |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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