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SEP-363856 mesylate
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Catalog No. T201258Cas No. 2375116-27-9
Alias SEP-856 mesylate
SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.
SEP-363856 mesylate
Copy Product Info😃Good
Catalog No. T201258Alias SEP-856 mesylateCas No. 2375116-27-9
SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | Inquiry | 3-6 months | 3-6 months | |
| 50 mg | Inquiry | 3-6 months | 3-6 months | |
| 100 mg | Inquiry | 3-6 months | 3-6 months |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia. |
| Targets&IC50 | 5-HT1A Receptor:2.3 μM (EC50, 5-HT1B Receptor:15.6 μM (EC50), 5-HT1D Receptor:0.262 μM (EC50), 5-HT7 Receptor:6.7 μM (EC50), 5-HT2C Receptor:30 μM (EC50), 5-HT2A Receptor:>10 μM (EC50), TAAR1:0.14 μM (EC50) |
| In vitro | SEP-856 mesylate (10 μM) demonstrates greater than 50% inhibition of specific binding at several receptors, including α2A, α2B, D2, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, and 5-HT7. |
| In vivo | SEP-856 mesylate, administered intraperitoneally (0.3, 1, and 10 mg/kg), demonstrates CNS activity and a behavioral profile akin to established antipsychotic medications. When given orally (0.3, 1, and 10 mg/kg, once), SEP-856 mesylate notably diminishes PCP-induced hyperactivity. Additionally, oral dosage of SEP-856 mesylate (1, 3, and 10 mg/kg) leads to a dose-dependent reduction in REM sleep, prolongation in the latency period to REM sleep, and an extension in cumulative wake (W) time. |
| Synonyms | SEP-856 mesylate |
| Molecular Weight | 279.38 |
| Formula | C10H17NO4S2 |
| Cas No. | 2375116-27-9 |
| Smiles | S(C)(=O)(=O)O.C(NC)[C@H]1C2=C(C=CS2)CCO1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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