dog

Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.

Sarolaner (PF-6450567) is an orally active, broad-spectrum ectoparasiticide with an LC80 of 0.3 μg/mL against C. felis and an LC100 of 0.003 μg/mL against O. turicata.

Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2, a G protein-coupled receptor for prostaglandin (PGD2), mediates key inflammatory responses related to allergy and asthma. PGD2, produced by mast cells, binds to CRTH2 on blood-borne cells, inducing chemotaxis of Th2 cells, basophils, and eosinophils, and stimulating cytokine release.

Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat), also known as Human PTHrP (107-111) amide, is a C-terminal fragment of parathyroid hormone-related protein that inhibits bone resorption [1][2].

DOG-IM4 is a chemical compound instrumental in synthesizing nanoparticles for delivering antigen-encoding nucleic acids, targeting a broad range of conditions including autoimmune diseases, rare blood or metabolic disorders, allergies, cancer, and infectious diseases [1].

S-Ac7-DOg is an ionizable cationic lipid used in the development of lipid nanoparticles and studies related to drug delivery.

C-Peptide, dog, is a component of proinsulin released from pancreatic beta cells into the blood alongside insulin. It plays a crucial role in the biosynthesis of insulin but has long been considered biologically inert.

Endogenous ligand for the canine KISS1 receptor (Kisspeptin receptor or GPR54). Stimulates section of luteinizing hormone, follicle stimulating hormone and estradiol in vivo.

Dog hair and epithelia extract is an allergen obtained from dog fur and epithelial samples, used for allergic reaction testing.

PAT-1251 is an inhibitor of LOXL2 with IC50s of 10, 0.12, and 0.16 μM for the mouse, rat, and dog and can be used in studies about fibrotic diseases.

AMG-548 is a selective and orally active p38α MAPK inhibitor (Ki = 0.5 nM), with higher selectivity than p38β, p38γ, and p38δ, and can also inhibit the TNFα, CK1δ/ε, and Wnt signalling pathways.

Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.

PAT-1251 Hydrochloride is a potent, selective, and oral inhibitor of lysyl oxidase-like 2 (LOXL2), targeting hLOXL2 and hLOXL3 with IC50 values of 0.71 and 1.17 μM, respectively.

VU6005806 is a potent positive allosteric modulator (PAM) of muscarinic acetylcholine receptor subtype 4 (M4) (EC50s: 94 nM, 28 nM, 87 nM, and 68 nM for human, rat, dog, and cyno M4, respectively), and used in the study of neuropsychiatric disorders.

Forodesine (BCX-1777) is an orally active and potent purine nucleoside phosphorylase (PNP) inhibitor, a new purine nucleoside analog, inhibitor of human lymphocyte proliferation, induces apoptosis in leukemic cells by increasing dGTP levels, and may be useful in the study of cutaneous T-cell lymphomas.

3-α- acetoxydihydrodeoxygeduin (3α DOG)is a kind of partial agonist GPR56.

Clopidogrel (SR-25990C), a P2Y12 receptor antagonist, decreases platelet aggregation.

Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets and platelet adhesion and aggregation.

(±) Clopidogrel hydrogen sulfate (Iscover) , an antiplatelet agent pharmacologically and structurally analogous to ticlopidine, is used to inhibit blood clots in various conditions such as cerebrovascular disease, peripheral vascular disease, and coronary artery disease.

Clopidogrel-related Compound B hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T125846 and the CAS number is 144750-52-7.

Clopidogrel carboxylic acid is a useful organic compound for research related to life sciences.

Clopidogrel Related Compound C is an isomer of Clopidogrel. Clopidogrel is a P2Y12 receptor antagonist that reduces platelet aggregation, used to prevent thrombotic events in coronary artery disease, peripheral artery disease, and cerebrovascular disease.

Edogesterone (PH-218) is a steroid compound characterized by its progestogenic and antiandrogenic properties.

Becondogrel (2-Oxoclopidogrel) is a metabolite of Clopidogrel. It irreversibly inhibits the P2Y12 receptor, thereby preventing platelet aggregation and thrombosis.