Search Result

Search Results for " 5-lox "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T77528	5-LOX-IN-2		Apoptosis , Lipoxygenase
	5-LOx-in-2 is a 5-lipoxygenase inhibitor (5-LOX) with an IC50 value of 0.33 μM. 5-lox-in-2 inhibits 5-LOX action IN a dose-dependent manner. 5-LOX-IN-2 can reduce the cell activity of kidney cancer cells and induce apopt...		Apoptosis , Lipoxygenase
T65427	5-LOX inhibitor	1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one	Lipoxygenase
	5-LOX inhibitor (1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one) is one of the impurities of itraconazole, a selective LOX-5 inhibitor.		Lipoxygenase
T61211	5-LOX-IN-1		Lipoxygenase
	5-LOX-IN-1 is a 5-Lipoxygenase (5-LOX) inhibitor (IC50: 2.3 μM).5-LOX-IN-1 can be used for cancer research.		Lipoxygenase
T8356	FPL 62064		Lipoxygenase , COX
	FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively).		Lipoxygenase , COX
T78820	5-LOX-IN-5		Lipoxygenase
	Compound 29, also known as 5-LOX-IN-5, is a 5-lipoxygenase (5-LOX) inhibitor with an inhibitory concentration 50 (IC50) of 56 nM, utilized in research pertaining to neurodegenerative diseases [1].		Lipoxygenase
T6893	MK-886	MK886,L 663536	Apoptosis , Leukotriene Receptor , COX , PPAR , FLAP
	MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.		Apoptosis , Leukotriene Receptor , COX , PPAR , FLAP
T60630	COX/5-LOX-IN-1
	COX/5-LOX-IN-1 (compound 6b) is a potent COX/5-LOX dual inhibitor with the potential for inflammation diseases research. COX/5-LOX-IN-1 has IC50s of 1.07, 0.55, and 0.28 μM for COX-1, COX-2, and 5-LOX enzyme, respectivel...
T61674	COX-2/5-LOX-IN-1
	COX-2/5-LOX-IN-1 (compound 3a), a benzothiophen-2-yl pyrazole carboxylic acid derivative, is a potent and dual inhibitor of COX-2 / 5-LOX. It exhibits superior analgesic and anti-inflammatory properties compared to Celec...
T61910	COX-2/5-LOX-IN-2
	COX-2/5-LOX-IN-2 is a benzothiophen-2-ylpyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 (5b) inhibited both COX-2 and 5-LOX. The IC50s of COX-2/5-LOX-IN-2 inhibiting COX-1, COX-2 and 5-LOX were 5.40, 0.01 and 1.78 ...
T61352	COX-2/5-LOX-IN-3
	COX-2/5-LOX-IN-3 (compound 5b) is a powerful and dual inhibitor of COX-2 and 5-LOX, with IC50 values of 45.73 μM, 5.45 μM, and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. This compound, COX-2/5-LOX-IN-3, shows pro...
T22502	2-TEDC		Lipoxygenase
	2-TEDC is a potent lipoxygenase (LOX) inhibitor with inhibitory effects on 5-LOX, 12-LOX, and 15-LOX with IC50 values of 0.09 μM, 0.013 μM, and 0.5 μM, respectively.2-TEDC can be used in the study of atherosclerosis.		Lipoxygenase
T6568	Licofelone	ML-3000	Apoptosis , Lipoxygenase , COX
	Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis. Licofelone is both an analgesic and an anti-inflammatory. Inhibition of 5-LOX may reduce the gastrointestinal toxicity ass...		Apoptosis , Lipoxygenase , COX
T16503	PF-4191834	PF-04191834	Lipoxygenase
	PF-4191834 is a noniron chelating and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) with an IC50 of 229 nM. PF-4191834 shows ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX and displays no activity toward the ...		Lipoxygenase
T21838	1-Naphthyl 3,5-dinitrobenzoate	JMC-4	Lipoxygenase
	1-Naphthyl 3,5-dinitrobenzoate (JMC-4) is an inhibitor of 5-LOX can be used in studies about inflammatory therapy.		Lipoxygenase
T25737	Linetastine	TMK 688,TMK-688,TMK688	Lipoxygenase , LTR , Histamine Receptor
	Linetastine (TMK-688) is a 5-lipoxygenase inhibitor (5-LOX) that inhibits leukotriene production and antagonizes the effects of histamine.Linetastine is used in studies of asthma, atherosclerosis, and peptic ulcers.		Lipoxygenase , LTR , Histamine Receptor
T34624	Setileuton	MK0633,MK 0633,MK-0633	Lipoxygenase
	Setileuton (MK0633) is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis.		Lipoxygenase
T8950	CAY10698		Lipoxygenase
	CAY10698 is a 12-lipoxygenase inhibitor (12-LO; IC50 of 5.1 µM).		Lipoxygenase
T27026L	CJ-13,610 hydrochloride		Lipoxygenase
	CJ-13,610 hydrochloride is an orally active nonredox-type inhibitor of 5-LOX and can be used in studies about the prevention of untoward pathophysiological effects of LTs.		Lipoxygenase
T9878	Croconazole		Lipoxygenase , LTR
	Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the synthesis of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraeno...		Lipoxygenase , LTR
T6576	Malotilate	Malotilatum,NKK 105,Kantec	Lipoxygenase
	Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis.		Lipoxygenase
T21902	ML351		Lipoxygenase
	ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).		Lipoxygenase
T68173	ZD-2138	Ici-D2138	Lipoxygenase
	ZD-2138 is a potent and selective specific inhibitor of 5-lipoxygenase (5-LOX) that inhibits allergen-induced pulmonary bronchoconstriction and reduces neurally-induced fast-acting kallikrein-ergic constriction of isolat...		Lipoxygenase
T50071	5-amino-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carbonitrile		Others
	5-amino-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carbonitrile is a compound used as a molecular structural unit and is considered to be an inhibitor of enzymes such as COX-2, 5-LOX, etc., and possesses a wide range of...		Others
T7724	Tepoxalin	RWJ-20485,RWJ20485,ORF20485,ORF-20485,RWJ 20485,ORF 20485	Lipoxygenase , COX
	Tepoxalin (RWJ 20485) is a 5-lipoxygenase inhibitor potentially for the treatment of asthma, osteoarthritis. Tepoxalin inhibits COX-1, COX-2, and 5-LOX. Tepoxalin is a potent inhibitor of sheep seminal vesicle cyclooxyge...		Lipoxygenase , COX
T8844	Diflapolin		Others , FLAP , Epoxide Hydrolase
	Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.		Others , FLAP , Epoxide Hydrolase
T1804	HPGDS inhibitor 1	HPGDS-inhibitor-1	PGE Synthase
	HPGDS inhibitor 1 is a novel and selective inhibitor for Hematopoietic Prostaglandin D Synthase (HPGDS) with an IC50 Value of 0.7 nM.		PGE Synthase
T10098	PGS-IN-1	KME-4	Lipoxygenase , Prostaglandin Receptor
	PGS-IN-1 (KME-4) is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).		Lipoxygenase , Prostaglandin Receptor
T10208	A-69412	N-1-(Fur-3-ylethyl)-N-hydroxyurea	Lipoxygenase
	A-69412 (N-1-(Fur-3-ylethyl)-N-hydroxyurea) is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase. It has the potential to treat ulcerative colitis and asthma, and possibly other inflammatory and allergic...		Lipoxygenase
T16817	S-2474		COX
	S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (IC50s: 11 nM and 27 μM for COX-2 and COX-1 in human intact cells).		COX
T71264	Tenidap Sodium
	Tenidap Sodium is a COX/5-LOX inhibitor and cytokine-modulating anti-inflammatory agent.
T27026	CJ-13,610	CJ 13610,CJ-13610	Lipoxygenase
	CJ-13,610 is an orally active and nonredox-type inhibitor of 5-lipoxygenase (5-LOX). CJ-13,610 inhibits the biosynthesis of leukotriene B4 and regulates the expression of IL-6 mRNA in macrophages.		Lipoxygenase
T19574	TBHBA	2,4,6-Tribromo-3-hydroxybenzoic acid	Others
	TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) is a brominated aromatic compound. It has been found to inhibit the enzyme cyclooxygenase-2 (COX-2), the enzyme lipoxygenase (LOX), the enzyme 5-lipoxygenase (5-LOX), the enzy...		Others
T78705	COX-2-IN-30		COX
	COX-2-IN-30, a benzenesulfonamide derivative, is an orally active, dual inhibitor of cyclooxygenase-2 (COX-2; IC50 = 49 nM) and cyclooxygenase-1 (COX-1; IC50 = 10.4 μM), as well as 5-lipoxygenase (5-LOX; IC50 = 2.4 μM). ...		COX
T63215	COX-2-IN-22
	COX-2-IN-22 is a COX-2 inhibitor (IC50: 8.6 μM) that can cross the blood-brain barrier and also exhibits inhibitory effects on AChE (IC50: 2.8 μM), BChE (IC50: 6.3 μM), β-Secretase (IC50: 15.3 μM), LOX-5 (IC50: 13.9 μM) ...
T81181	SEH/FLAP-IN-1		FLAP
	sEH/FLAP-IN-1 (Compound 46A) serves as a dual inhibitor targeting both sEH and FLAP. It effectively suppresses 5-LOX product formation with an EC50 of 11 nM in SACM-stimulated PBMCs and also inhibits sEH activity (EC50: ...		FLAP
T22172	YS-121
	YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 ( mPGES-1; IC 50 =3.4 μM) and 5-lipoxygenase ( 5-LOX; IC 50 =6.5 μM). YS121 dose-dependently reduces the production of PGE2 with EC 50 =12 μM in IL-1β-s...
T78706	COX-2-IN-31		COX
	COX-2-IN-31 (compound 7b) is an orally active dual inhibitor targeting COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM). Additionally, it inhibits the activity of transmembrane hCA IX (Ki=48.9 nM) and hCA XII (Ki=5.8 nM). This...		COX
T22054	BW 755C		Lipoxygenase
	BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.		Lipoxygenase
T37805	JKE-1716
	JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additi...
T15783	LP117		Others
	LP117 is a novel and effective inhibitor of 5-Lipoxygenase (5-LO) product synthesis (IC50: 1.1 μM).		Others
T13263	COX/5-LO-IN-1	Atreleuton analog	COX
	COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.		COX
T10844	CMI-392		Others
	CMI-392 is a dual 5-lipoxygenase inhibitor and platelet-activating factor (PAF) receptor antagonist (IC50s: 100 and 10 nM).		Others
T11864	Iptacopan	LNP023	Others
	Iptacopan (LNP023) is an inhibitor with high affinity for factor B.		Others

Compounds

5-LOX-IN-2

T77528

Synonym:

Target: Apoptosis, Lipoxygenase

5-LOX inhibitor

T65427

Synonym: 1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

Target: Lipoxygenase, COX

Synonym: MK886,L 663536

Target: Apoptosis, Leukotriene Receptor, COX, PPAR, FLAP

Target: Apoptosis, Lipoxygenase, COX

1-Naphthyl 3,5-dinitrobenzoate

Synonym: TMK 688,TMK-688,TMK688

Target: Lipoxygenase, LTR, Histamine Receptor

Setileuton

T34624

Synonym: MK0633,MK 0633,MK-0633

CJ-13,610 hydrochloride

Target: Lipoxygenase, LTR

Malotilate

T6576

Synonym: Malotilatum,NKK 105,Kantec

5-amino-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carbonitrile

Synonym: RWJ-20485,RWJ20485,ORF20485,ORF-20485,RWJ 20485,ORF 20485

Target: Lipoxygenase, COX

Diflapolin

T8844

Synonym:

Target: Others, FLAP, Epoxide Hydrolase

HPGDS inhibitor 1

T1804

Synonym: HPGDS-inhibitor-1

Target: Lipoxygenase, Prostaglandin Receptor

A-69412

T10208

Synonym: N-1-(Fur-3-ylethyl)-N-hydroxyurea

Synonym: CJ 13610,CJ-13610

Target: Lipoxygenase

TBHBA

T19574

Synonym: 2,4,6-Tribromo-3-hydroxybenzoic acid

Synonym: Atreleuton analog

Cat No.	Product Name	Synonyms	Targets
T8260	4',5-Dihydroxyflavone		Lipoxygenase , Glucosidase
	4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).		Lipoxygenase , Glucosidase
T6S0413	Pectolinarigenin	Pectolinaringenin	Others , Lipoxygenase , COX
	1. Pectolinarigenin (Pectolinaringenin) exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory activity and that they may inhibit eicosanoid formation in ...		Others , Lipoxygenase , COX
T5714	5-O-Demethylnobiletin	5-DEMETHYLNOBILETIN	Leukotriene Receptor , Lipoxygenase
	5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2.		Leukotriene Receptor , Lipoxygenase
T3399	Psoralidin		Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial
	Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties.
TN2330	Phenethyl ferulate	Caffeic Acid 3-Methyl Phenethyl Ester	Lipoxygenase , COX
	Phenethyl ferulate (Caffeic Acid 3-Methyl Phenethyl Ester) has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis in azoxymethane induced colon tumors. It shows inhibitory a...		Lipoxygenase , COX
T3S0153	Xanthatin		Apoptosis , VEGFR , Lipoxygenase , Wnt/beta-catenin , Antibacterial
	1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSCLC. 4. Xanthatin can inhibit murine melanoma B16-F1 cell pr...
T5759	S-(+)-Marmesin	(+)-Marmesin,(S)-Marmesin,marmesin	Lipoxygenase , COX
	S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.		Lipoxygenase , COX
TN1182	11-Keto-beta-boswellic acid	11-Keto-beta-boswellic acid	Leukotriene Receptor , NF-κB , Lipoxygenase
	11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenas...		Leukotriene Receptor , NF-κB , Lipoxygenase
TN1308	6-Hydroxyflavanone		Others , Lipoxygenase , COX , GABA Receptor
	6-Hydroxyflavanone, extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), as well as opioid and GABA-A r...		Others , Lipoxygenase , COX , GABA Receptor
T3090	Abietic Acid	Rosin Acid,L-Abietic acid,Sylvic acid,Abietate	MMP , Lipoxygenase , Antibacterial , PPAR
	Abietic Acid (Sylvic acid) is the primary component of resin acid isolated from rosin.		MMP , Lipoxygenase , Antibacterial , PPAR
TJS2190	Nordihydroguaiaretic acid	NDGA,Dihydronorguaiaretic Acid	Antioxidant , Ferroptosis , Lipoxygenase , Autophagy
	Nordihydroguaiaretic acid (NDGA) (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibito...		Antioxidant , Ferroptosis , Lipoxygenase , Autophagy
T3384	Wedelolactone	IKK Inhibitor II	Apoptosis , NF-κB , Lipoxygenase , Caspase
	Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.		Apoptosis , NF-κB , Lipoxygenase , Caspase

Natural Products

4',5-Dihydroxyflavone

T8260

Synonym:

Target: Lipoxygenase, Glucosidase

Pectolinarigenin

T6S0413

Synonym: Pectolinaringenin

Target: Others, Lipoxygenase, COX

5-O-Demethylnobiletin

T5714

Synonym: 5-DEMETHYLNOBILETIN

Target: Leukotriene Receptor, Lipoxygenase

Psoralidin

T3399

Synonym:

Target: Others, Estrogen/progestogen Receptor, Reactive Oxygen Species, Lipoxygenase, Gamma-secretase, Akt, COX, Antibacterial

Phenethyl ferulate

TN2330

Synonym: Caffeic Acid 3-Methyl Phenethyl Ester

Target: Lipoxygenase, COX

Xanthatin

T3S0153

Synonym:

Target: Apoptosis, VEGFR, Lipoxygenase, Wnt/beta-catenin, Antibacterial

S-(+)-Marmesin

T5759

Synonym: (+)-Marmesin,(S)-Marmesin,marmesin

Target: Lipoxygenase, COX

11-Keto-beta-boswellic acid

TN1182

Synonym: 11-Keto-beta-boswellic acid

Target: Leukotriene Receptor, NF-κB, Lipoxygenase

6-Hydroxyflavanone

TN1308

Synonym:

Target: Others, Lipoxygenase, COX, GABA Receptor

Abietic Acid

T3090

Synonym: Rosin Acid,L-Abietic acid,Sylvic acid,Abietate

Target: MMP, Lipoxygenase, Antibacterial, PPAR

Nordihydroguaiaretic acid

TJS2190

Synonym: NDGA,Dihydronorguaiaretic Acid

Target: Antioxidant, Ferroptosis, Lipoxygenase, Autophagy

Wedelolactone

T3384

Synonym: IKK Inhibitor II

Target: Apoptosis, NF-κB, Lipoxygenase, Caspase

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-05308	CD45 Protein, Human, Recombinant (aa 1-529, His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05387	SLAMF7 Protein, Human, Recombinant (hFc)	Human	HEK293
	SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 ...
TMPY-05498	SR-BI/SCARB1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Scavenger receptor class B, member 1 (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non placental steroidogenic tissues, and predominantly localiz...
TMPJ-00854	ETS1 Protein, Human, Recombinant (His)	Human	E. coli
	ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or ...
TMPY-05547	SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated	Human	HEK293
	SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 ...
TMPY-04318	GRIK2 Protein, Human, Recombinant (hFc)	Human	HEK293
	GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar...
TMPK-01363	SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl...
TMPK-01357	SIRP alpha V5 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl...