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LY310762

Name: LY310762
Brand: TargetMol
SKU: T2688
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2688Cas No. 192927-92-7

Alias LY310762 HCl

LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.

LY310762

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Purity: 99.8%

Catalog No. T2688Alias LY310762 HClCas No. 192927-92-7

LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$29	In Stock	In Stock
10 mg	$43	In Stock	In Stock
25 mg	$88	In Stock	In Stock
50 mg	$142	In Stock	In Stock
100 mg	$229	In Stock	In Stock
200 mg	$347	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.8%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.
Targets&IC50	5-HT1D:249 nM(Ki)
In vitro	Following treatment with LY310762, the levels of 5-HT in animals treated with fluoxetine increased from 312±43% to a peak of 683%. In the control group, the 5-HT levels remained constant at 250%. Compared to animals that received a control vehicle injection, systemic administration of 10 mg/kg i.p. LY310762 significantly enhanced the response of 5-HT to 20 mg/kg i.p. fluoxetine. When administered alone, LY310762 notably raised the baseline levels of 5-HT above the vehicle control, achieving a maximum value of 258% compared to the pre-injection control group.
In vivo	LY310762 enhances potassium-induced [3H] 5-HT efflux from guinea pig cortical slices, with an EC50 of 30 nM. The maximal enhancement of potassium-induced [3H]5-HT efflux by LY310762 is approximately 40%. LY310762 exhibits a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor.
Synonyms	LY310762 HCl

Chemical Properties

Molecular Weight	430.94
Formula	C₂₄H₂₇FN₂O₂·HCl
Cas No.	192927-92-7
Smiles	Cl.CC1(C)C(=O)N(CCN2CCC(CC2)C(=O)c2ccc(F)cc2)c2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 43.1 mg/mL (100.01 mM), Sonication is recommended.

H2O: 4.31 mg/mL (10 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3205 mL	11.6025 mL	23.2051 mL	116.0254 mL
5 mM	0.4641 mL	2.3205 mL	4.6410 mL	23.2051 mL
10 mM	0.2321 mL	1.1603 mL	2.3205 mL	11.6025 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1160 mL	0.5801 mL	1.1603 mL	5.8013 mL
50 mM	0.0464 mL	0.2321 mL	0.4641 mL	2.3205 mL
100 mM	0.0232 mL	0.1160 mL	0.2321 mL	1.1603 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc