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LY310762

Name: LY310762
Brand: TargetMol
SKU: T2688
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2688Cas No. 192927-92-7

Alias LY310762 HCl

LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.

LY310762

🥰Excellent

Purity: 99.8%

Catalog No. T2688Alias LY310762 HClCas No. 192927-92-7

LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.

Pack Size	Price	Availability
5 mg	$29	In Stock
10 mg	$43	In Stock
25 mg	$88	In Stock
50 mg	$142	In Stock
100 mg	$229	In Stock
200 mg	$347	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.8%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.
Targets&IC50	5-HT1D:249 nM(Ki)
In vitro	Following treatment with LY310762, the levels of 5-HT in animals treated with fluoxetine increased from 312±43% to a peak of 683%. In the control group, the 5-HT levels remained constant at 250%. Compared to animals that received a control vehicle injection, systemic administration of 10 mg/kg i.p. LY310762 significantly enhanced the response of 5-HT to 20 mg/kg i.p. fluoxetine. When administered alone, LY310762 notably raised the baseline levels of 5-HT above the vehicle control, achieving a maximum value of 258% compared to the pre-injection control group.
In vivo	LY310762 enhances potassium-induced [3H] 5-HT efflux from guinea pig cortical slices, with an EC50 of 30 nM. The maximal enhancement of potassium-induced [3H]5-HT efflux by LY310762 is approximately 40%. LY310762 exhibits a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor.
Synonyms	LY310762 HCl

Chemical Properties

Molecular Weight	430.94
Formula	C₂₄H₂₇FN₂O₂·HCl
Cas No.	192927-92-7
Smiles	Cl.CC1(C)C(=O)N(CCN2CCC(CC2)C(=O)c2ccc(F)cc2)c2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 43.1 mg/mL (100.01 mM), Sonication is recommended.

H2O: 4.3 mg/mL (9.98 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3205 mL	11.6025 mL	23.2051 mL	116.0254 mL
5 mM	0.4641 mL	2.3205 mL	4.6410 mL	23.2051 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2321 mL	1.1603 mL	2.3205 mL	11.6025 mL
20 mM	0.1160 mL	0.5801 mL	1.1603 mL	5.8013 mL
50 mM	0.0464 mL	0.2321 mL	0.4641 mL	2.3205 mL
100 mM	0.0232 mL	0.1160 mL	0.2321 mL	1.1603 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc