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Turosteride

Catalog No. T71703 CAS 137099-09-3

Turosteride is a small molecule steroidal 5α-reductase (5α-reductase) inhibitor.Turosteride has antitumor activity for the treatment of oncologic diseases and genitourinary disorders, and may be used in the study of prostate cancer.

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Turosteride, CAS 137099-09-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 130.00
5 mg	In stock	$ 320.00
10 mg	In stock	$ 480.00
25 mg	In stock	$ 786.00
50 mg	In stock	$ 1,080.00
100 mg	In stock	$ 1,480.00

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Biological Description

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Description

In vivo

Turosteride caused inhibition of rat and human prostatic enzymes, with IC50 values of 55 and 53 nM, respectively. In addition, turosteride did not show any relevant binding affinity to the rat prostate androgen receptor (IC50 84 μM; relative binding affinity 0.004% of DHT). The endocrine effects of turosteride were evaluated in adult male rats, treated orally at daily doses of 3, 10 and 30 mg/kg for 20 days. At these doses, the compound reduced the ventral prostate weight by 10, 33 and 42% and the intraprostatic total DHT content by 61, 74 and 78%, respectively, whereas no change in the intraprostatic content of T was observed. Turosteride caused a 40% reduction of serum DHT levels which, however, did not reach statistical significance, whereas serum T levels were similar to control animals. No effect on serum luteinizing hormone or prolactin was observed. These results indicate that the antiprostatic effect of turosteride in the adult rat is related to inhibition of the conversion of T to DHT.[1]

Molecular Weight	459.66
Formula	C27H45N3O3
CAS No.	137099-09-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (97.9 mM)

References and Literature

1. di Salle E, et al. Hormonal effects of turosteride, a 5 alpha-reductase inhibitor, in the rat. J Steroid Biochem Mol Biol. 1993;46(5):549-555. 2. Di Salle E, et al. Endocrine properties of the testosterone 5 alpha-reductase inhibitor turosteride (FCE 26073). J Steroid Biochem Mol Biol. 1994;48(2-3):241-248.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

Turosteride 137099-09-3 Endocrinology/Hormones Metabolism Reductase inhibitor inhibit

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