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Elamipretide acetate

Catalog No. TP1095L

Synonyms: MTP 131 acetate, Elamipretide acetate (736992-21-5 Free base)

Elamipretide acetate (MTP 131 acetate) is a derivative of Elamipretide, a small mitochondria-targeting tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that can be used in studies to reduce the production of toxic reactive oxygen species and stabilize cardiolipin.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Elamipretide acetate, CAS N/A

Pack Size	Availability	Price/USD
1 mg	Inquiry	$ 59.00
5 mg	Inquiry	$ 125.00
10 mg	Inquiry	$ 193.00
25 mg	Inquiry	$ 375.00
50 mg	Inquiry	$ 496.00
100 mg	Inquiry	$ 761.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Elamipretide acetate (MTP 131 acetate) is a derivative of Elamipretide, a small mitochondria-targeting tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that can be used in studies to reduce the production of toxic reactive oxygen species and stabilize cardiolipin.
In vitro	In vitro experiment it exhibited that treatment with 1 µM elamipretide in cultured ARPE-19 cells results in accelerating an increase in mitochondrial volume.[3] In vitro, added in the freeze media with 1 and 10 µM Elamipretide obviously improved post-thaw sperm parameters including motility and viability, stability of the plasma membrane, and mitochondria and chromosomes.[4] In control INS1 cells, treatment with 1 µM Elamipretide for 20 h suffiently increase the engulfment of mitochondria into autophagosomes, but it has no increase at 10 µM Elamipretide, suggesting a complete reversal of mitochondrial fragmentation induced by nutrient excess at 10 µM, while not being complete at 1 µM.[5]
In vivo	In vivo, 1 mg/kg MTP-131 treatment reversed visual decline without improving glycemic control or reducing body weight in diabetic mouse models.[6] In vivo test it shown that treatment repeatedly with 5 mg/kg elamipretide intraperitoneally in mice provided maximum neuroprotective effects without any adverse effects[7]. Treatment with 3 mg/kg/day SS-31 (elamipretide) restored redox homeostasis, improved mitochondrial quality, and increased exercise tolerance without an increase in mitochondrial content in aged mice.[8]

Synonyms	MTP 131 acetate, Elamipretide acetate (736992-21-5 Free base)
Molecular Weight	699.84
Formula	C34H53N9O7

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Dai DF, et al. Global proteomics and pathway analysis of pressure-overload-induced heart failure and its attenuation by mitochondrial-targeted peptides. Circ Heart Fail. 2013;6(5):1067-1076. 2. Zhao K, et al. Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines. Biochem Pharmacol. 2005;70(12):1796-1806. 3. Grosser JA, et al. The effects of a mitochondrial targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis. BMC Res Notes. 2021;14(1):198. 4. Bai H, et al. Elamipretide as a potential candidate for relieving cryodamage to human spermatozoa during cryopreservation. Cryobiology. 2020;95:138-142. 5. Petcherski A, et al. Elamipretide Promotes Mitophagosome Formation and Prevents Its Reduction Induced by Nutrient Excess in INS1 β-cells. J Mol Biol. 2018;430(24):4823-4833. 6. Alam NM, et al. A mitochondrial therapeutic reverses visual decline in mouse models of diabetes. Dis Model Mech. 2015;8(7):701-710. 7. Zhao W, et al. Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice. J Neuroinflammation. 2019;16(1):230. 8. Campbell MD, et al. Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice. Free Radic Biol Med. 2019;134:268-281.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Elamipretide acetate 736992-21-5 Free base MTP 131 Acetate MTP 131 acetate Elamipretide Acetate MTP131 Acetate 736992-21-5 MTP-131 Acetate Elamipretide acetate (736992-21-5 Free base) inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.