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Sevoflurane
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Catalog No. T22425Cas No. 28523-86-6
Alias Fluoromethyl
Sevoflurane (Fluoromethyl), a noncompetitive inhibitor of 5-HT3 receptor, acts as a low-soluble inhalation anesthetics.
Sevoflurane
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Purity: 98%
Catalog No. T22425Alias FluoromethylCas No. 28523-86-6
Sevoflurane (Fluoromethyl), a noncompetitive inhibitor of 5-HT3 receptor, acts as a low-soluble inhalation anesthetics.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $35 | In Stock | In Stock | |
| 5 mg | $52 | In Stock | In Stock | |
| 10 mg | $73 | In Stock | In Stock | |
| 25 mg | $118 | In Stock | In Stock | |
| 50 mg | $169 | In Stock | In Stock | |
| 100 mg | $252 | In Stock | In Stock | |
| 200 mg | $377 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $54 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98%
Color:Transparent
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Product Introduction
Sevoflurane AI Summary
Sevoflurane exhibits bioactivities associated with liver enzyme function, including a marginal to active composite activity with increases in alkaline phosphatase and moderate increases in serum glutamic oxaloacetic transaminase (SGOT) index values. Slight increases in lactate dehydrogenase (LDH) enzyme activity were also observed, while serum glutamic pyruvic transaminase (SGPT) and gamma-glutamyl transferase (GGT) activities were not significantly affected. The compound demonstrates moderate partitioning characteristics between blood and lung compartments with a slightly higher partition coefficient for lung (logP(lung) = 0.31; logK(blood) = -0.2) and moderate affinity for lung tissue (logK(lung) = 0.11). In malaria studies, it acts as a delayed death inhibitor of the malarial parasite plastid with a potency of 10417.9 nM. Additionally, Sevoflurane shows bioactivities related to hepatic side effects, with high scores for hepatic failure, hepatitis, hepatic necrosis, and jaundice, indicating significant liver toxicity and a 40.0% frequency of moderate hepatotoxicity in clinical trials. It also presents 6.0% acute liver toxicity, particularly cytolytic hepatotoxicity, and reports of severe hepatitis, though no chronic liver disease, cirrhosis, granulomatous hepatitis, steatosis, or tumors were observed. The compound is involved in drug metabolism in humans with an assay result showing 2.0% drug metabolism..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Sevoflurane (Fluoromethyl), a noncompetitive inhibitor of 5-HT3 receptor, acts as a low-soluble inhalation anesthetics. |
| Synonyms | Fluoromethyl |
| Molecular Weight | 200.05 |
| Formula | C4H3F7O |
| Cas No. | 28523-86-6 |
| Smiles | FCOC(C(F)(F)F)C(F)(F)F |
| Relative Density. | 1.505 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (1249.69 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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