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PNU 22394 hydrochloride

Name: PNU 22394 hydrochloride
Brand: TargetMol
SKU: T23168
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23168Cas No. 15923-42-9

PNU 22394 hydrochloride is a 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist

PNU 22394 hydrochloride

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Purity: 97.83%

Catalog No. T23168Cas No. 15923-42-9

PNU 22394 hydrochloride is a 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$151	In Stock	In Stock
25 mg	$271	In Stock	In Stock
50 mg	$397	In Stock	In Stock
100 mg	$568	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.83%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

PNU 22394 hydrochloride AI Summary

PNU 22394 hydrochloride demonstrates a diverse range of bioactivities. It acts as an inhibitor of HSD17B4 (hydroxysteroid dehydrogenase 4) with a potency of 25118.9 nM, JMJD2E (Jumonji Domain Containing 2E) with a potency of 35481.3 nM, and 15-hLO (15-human lipoxygenase) with a potency of 39810.7 nM. Additionally, it inhibits 15-hLO-2 (15-human lipoxygenase 2) at a potency of 19952.6 nM and the ERK signaling pathway when stimulated with EGF, also at 35481.3 nM. Furthermore, it demonstrates the capacity to erase genomic imprints at a potency of 10000.0 nM, and it inhibits anthrax lethal toxin internalization at a potency of 5011.9 nM. In antiviral research, PNU 22394 hydrochloride inhibits SARS-CoV-2 induced cytotoxicity of Caco-2 cells at a 10 uM concentration after 48 hours, showing an inhibition rate of 0.61%. It also inhibits SARS-CoV-2 induced cytotoxicity of VERO-6 cells at the same concentration, with an inhibition rate of -0.08% after 48 hours exposure to 0.01 MOI SARS-CoV-2 virus. In enzymatic assays, it shows inhibitory activity against SARS-CoV-2 3CL-Pro protease at a concentration of 20 µM, though with a recorded inhibition of -3.642% as measured via a FRET assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

PNU 22394 hydrochloride is a 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist

Chemical Properties

Molecular Weight	236.74
Formula	C₁₃H₁₇ClN₂
Cas No.	15923-42-9
Smiles	CN1C(CCNCC2)=C2C3=C1C=CC=C3.[H]Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 23 mg/mL (97.15 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.2240 mL	21.1202 mL	42.2404 mL	211.2022 mL
5 mM	0.8448 mL	4.2240 mL	8.4481 mL	42.2404 mL
10 mM	0.4224 mL	2.1120 mL	4.2240 mL	21.1202 mL
20 mM	0.2112 mL	1.0560 mL	2.1120 mL	10.5601 mL
50 mM	0.0845 mL	0.4224 mL	0.8448 mL	4.2240 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc