Shopping Cart

Your shopping cart is currently empty

Cyamemazine

Name: Cyamemazine
Brand: TargetMol
SKU: T15026
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T15026Cas No. 3546-03-0

Cyamemazine is an antipsychotic compound with sedative and anxiolytic activity. Cyamemazine is a 5-HT3, 5-HT2A, and 5-HT2C receptor antagonist with Ki values of 12 nM, 1.5 nM, and 75 nM, respectively.

Cyamemazine

😃Good

Purity: 97.01%

Catalog No. T15026Cas No. 3546-03-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	-	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$106	In Stock	In Stock
25 mg	$222	-	In Stock
50 mg	$378	-	In Stock
100 mg	$645	-	In Stock
1 mL x 10 mM (in DMSO)	$71	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:97.01%

Appearance:Oil

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Cyamemazine is an antipsychotic compound with sedative and anxiolytic activity. Cyamemazine is a 5-HT3, 5-HT2A, and 5-HT2C receptor antagonist with Ki values of 12 nM, 1.5 nM, and 75 nM, respectively.
Targets&IC50	5-HT3 Receptor:75 nM （Ki）, 5-HT2C Receptor:12 nM （Ki）, 5-HT2A Receptor:1.5 nM （Ki）
In vitro	METHODS: The antagonistic effects of Cyamemazine on various receptors, such as D2, 5-HT2A, 5-HT2C, and 5-HT3 receptors, were determined through binding experiments. RESULTS: Cyamemazine showed strong antagonistic effects on D2 and 5-HT2A receptors, and relatively weaker antagonistic effects on 5-HT2C and 5-HT3 receptors. This receptor activity is associated with its anxiolytic effects [1].
In vivo	METHODS: The Elevated Plus Maze (EPM) test was conducted in mice to evaluate the anxiolytic-like behavior of Cyamemazine under acute and chronic dosing conditions. RESULTS: In the acute dosing condition, Cyamemazine exhibited anxiolytic-like activity in the light/dark exploration test. In the chronic dosing condition, it increased the time spent in the open arms of the Elevated Plus Maze, demonstrating its anxiolytic effects [1].

Chemical Properties

Molecular Weight	323.46
Formula	C₁₉H₂₁N₃S
Cas No.	3546-03-0
Smiles	N#CC1=CC=C2SC=3C=CC=CC3N(C2=C1)CC(C)CN(C)C
Relative Density.	1.21 g/cm3

Storage & Solubility Information

Storage

store under nitrogen | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (247.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0916 mL	15.4579 mL	30.9157 mL	154.5786 mL
5 mM	0.6183 mL	3.0916 mL	6.1831 mL	30.9157 mL
10 mM	0.3092 mL	1.5458 mL	3.0916 mL	15.4579 mL
20 mM	0.1546 mL	0.7729 mL	1.5458 mL	7.7289 mL
50 mM	0.0618 mL	0.3092 mL	0.6183 mL	3.0916 mL
100 mM	0.0309 mL	0.1546 mL	0.3092 mL	1.5458 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc