Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TRC-766, a negative control of RTC-5 (TRC-382), is a compound that exhibits protein phosphatase 2A (PP2A) binding properties while lacking phosphatase activation capabilities.
Description | TRC-766, a negative control of RTC-5 (TRC-382), is a compound that exhibits protein phosphatase 2A (PP2A) binding properties while lacking phosphatase activation capabilities. |
In vitro | As a pharmacological control, cells undergo treatment with escalating doses of TRC-766, a compound structurally akin to PP2A (SMAP) yet devoid of biological activity. TRC-766's absence of a critical N-H sulfonamide hydrogen bond donor differentiates it from active counterparts. Although it binds to PP2A, TRC-766 fails to trigger the phosphatase's activation, leading to the hypothesis that it does not impact cell viability[1]. |
Molecular Weight | 524.98 |
Formula | C25H24ClF3N2O3S |
CAS No. | 1810734-44-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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TRC-766 1810734-44-1 TRC 766 TRC766 inhibitor inhibit