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Cdk5 Substrate

Name: Cdk5 Substrate
Brand: TargetMol
SKU: T37207
Rating: 4.5 (1 reviews)

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Catalog No. T37207Cas No. 164669-07-2

Alias Cdk5 Substrate

Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 substrate is a synthetic peptide (PKTPKKAKKL) corresponding to a sequence of histone H1. It is phosphorylated by Cdk5 with a Km value of 5 μM.

Cdk5 Substrate

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Catalog No. T37207Alias Cdk5 SubstrateCas No. 164669-07-2

Pack Size	Price	Availability
1 mg	$117	Backorder
5 mg	$489	Backorder
10 mg	$770	Backorder

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Product Introduction

Bioactivity

Description	Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 substrate is a synthetic peptide (PKTPKKAKKL) corresponding to a sequence of histone H1. It is phosphorylated by Cdk5 with a Km value of 5 μM.
Synonyms	Cdk5 Substrate

Chemical Properties

Molecular Weight	1138.45
Formula	C₅₃H₉₉N₁₅O₁₂
Cas No.	164669-07-2
Sequence	Pro-Lys-Thr-Pro-Lys-Lys-Ala-Lys-Lys-Leu
Sequence Short	PKTPKKAKKL

Storage & Solubility Information

Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	PBS (pH 7.2): 10 mg/mL (8.78 mM), Sonication is recommended. DMF: 10 mg/mL (8.78 mM), Sonication is recommended. Ethanol: 1 mg/mL (0.88 mM), Sonication is recommended. DMSO: 20 mg/mL (17.57 mM), Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Cdk-5 Substrate