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Ramosetron

Name: Ramosetron
Brand: TargetMol
SKU: T4562
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4562Cas No. 132036-88-5

Ramosetron is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting. It is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists such as ondansetron. Ramosetron is also indicated for a treatment of "diarrhea-predominant irritable bowel syndrome in males". It is only licensed for use in Japan and selected Southeast Asian countries.

Ramosetron

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Purity: 98.84%

Catalog No. T4562Cas No. 132036-88-5

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$40	In Stock	In Stock
50 mg	$68	In Stock	In Stock
100 mg	$100	In Stock	In Stock
200 mg	$153	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.84%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Ramosetron AI Summary

Ramosetron is a multifunctional molecule displaying a variety of bioactivities. It shows strong binding affinity to the human 5HT3A receptor with a Ki of 0.06 nM and demonstrates partial agonist activity at this receptor by reducing intracellular calcium release at 3 µM in HEK293 cells. In the PUBCHEM_BIOASSAY S16 Schwann cell viability assay, it has a potency of 3.2 nM. Additionally, it exhibits antiviral activity against the SARS-CoV-2 virus in several assays; it showed moderate antiviral activity in HRCE cells against the USA-WA1/2020 strain at MOI 0.4 for 96 hrs, inhibited SARS-CoV-2 3CL-Pro protease activity by 14.21% at 20 µM, and showed inhibition of SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM. However, the potency in inhibiting the virus indicated by IC50 values (>20000.0 nM and >19952.62 nM) suggests limited efficacy at tested concentrations. Furthermore, Ramosetron exhibits inhibitory activity on the human HDAC6 enzyme with -23.53% inhibition using a commercial peptide substrate and 3.12% inhibition with a custom peptide substrate. It also shows binding affinity to several other receptors, including ADRA2B, OPRK1, and ADRA2A, with various AC50 values, and functions as an antagonist at ADRA2A and an agonist at HRH2, ADRA2A, and PGR with relatively low efficacy at specified concentrations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	279.34
Formula	C₁₇H₁₇N₃O
Cas No.	132036-88-5
Smiles	C(=O)(C=1C=2C(N(C)C1)=CC=CC2)[C@H]3CC4=C(CC3)N=CN4
Relative Density.	1.33g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (161.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5799 mL	17.8993 mL	35.7987 mL	178.9933 mL
5 mM	0.7160 mL	3.5799 mL	7.1597 mL	35.7987 mL
10 mM	0.3580 mL	1.7899 mL	3.5799 mL	17.8993 mL
20 mM	0.1790 mL	0.8950 mL	1.7899 mL	8.9497 mL
50 mM	0.0716 mL	0.3580 mL	0.7160 mL	3.5799 mL
100 mM	0.0358 mL	0.1790 mL	0.3580 mL	1.7899 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc