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Clothiapine

Name: Clothiapine
Brand: TargetMol
SKU: T23900
Price: 99 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23900Cas No. 2058-52-8

Alias S-805C, LW 2159, HF-2159, HF2159, HF 2159

Clothiapine (HF 2159) is an atypical antipsychotic agent with potent anti 5-hydroxytryptaminergic and serotonergic activity, which has been used in the study of schizophrenia.

Clothiapine

🥰Excellent

Purity: 99.93%

Catalog No. T23900Alias S-805C, LW 2159, HF-2159, HF2159, HF 2159Cas No. 2058-52-8

Clothiapine (HF 2159) is an atypical antipsychotic agent with potent anti 5-hydroxytryptaminergic and serotonergic activity, which has been used in the study of schizophrenia.

Pack Size	Price	Availability	Quantity
1 mg	$99	In Stock

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Purity:99.93%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Clothiapine (HF 2159) is an atypical antipsychotic agent with potent anti 5-hydroxytryptaminergic and serotonergic activity, which has been used in the study of schizophrenia.
In vitro	The effect of thiophene on ATPase activity and associated oxygen uptake as assessed by photoelectric， Clothiapine was investigated at 1-0.001 mM. 0.1 mM Clothiapine inhibited sodium-potassium ATPase activity and associated QO2 by 30-40%.[5]
Synonyms	S-805C, LW 2159, HF-2159, HF2159, HF 2159

Chemical Properties

Molecular Weight	343.87
Formula	C₁₈H₁₈ClN₃S
Cas No.	2058-52-8
Smiles	ClC=1C=CC=2SC=3C=CC=CC3N=C(C2C1)N4CCN(C)CC4
Relative Density.	1.33g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (145.40 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9081 mL	14.5404 mL	29.0808 mL	145.4038 mL
5 mM	0.5816 mL	2.9081 mL	5.8162 mL	29.0808 mL
10 mM	0.2908 mL	1.4540 mL	2.9081 mL	14.5404 mL
20 mM	0.1454 mL	0.7270 mL	1.4540 mL	7.2702 mL
50 mM	0.0582 mL	0.2908 mL	0.5816 mL	2.9081 mL
100 mM	0.0291 mL	0.1454 mL	0.2908 mL	1.4540 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc