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Clothiapine

Name: Clothiapine
Brand: TargetMol
SKU: T23900
Price: 99 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23900Cas No. 2058-52-8

Alias S-805C, LW 2159, HF-2159, HF2159, HF 2159

Clothiapine (HF 2159) is an atypical antipsychotic agent with potent anti 5-hydroxytryptaminergic and serotonergic activity, which has been used in the study of schizophrenia.

Clothiapine

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Purity: 99.93%

Catalog No. T23900Alias S-805C, LW 2159, HF-2159, HF2159, HF 2159Cas No. 2058-52-8

Clothiapine (HF 2159) is an atypical antipsychotic agent with potent anti 5-hydroxytryptaminergic and serotonergic activity, which has been used in the study of schizophrenia.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$99	-	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.93%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Clothiapine (HF 2159) is an atypical antipsychotic agent with potent anti 5-hydroxytryptaminergic and serotonergic activity, which has been used in the study of schizophrenia.
In vitro	The effect of thiophene on ATPase activity and associated oxygen uptake as assessed by photoelectric， Clothiapine was investigated at 1-0.001 mM. 0.1 mM Clothiapine inhibited sodium-potassium ATPase activity and associated QO2 by 30-40%.[5]
Synonyms	S-805C, LW 2159, HF-2159, HF2159, HF 2159

Chemical Properties

Molecular Weight	343.87
Formula	C₁₈H₁₈ClN₃S
Cas No.	2058-52-8
Smiles	ClC=1C=CC=2SC=3C=CC=CC3N=C(C2C1)N4CCN(C)CC4
Relative Density.	1.33g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (145.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9081 mL	14.5404 mL	29.0808 mL	145.4038 mL
5 mM	0.5816 mL	2.9081 mL	5.8162 mL	29.0808 mL
10 mM	0.2908 mL	1.4540 mL	2.9081 mL	14.5404 mL
20 mM	0.1454 mL	0.7270 mL	1.4540 mL	7.2702 mL
50 mM	0.0582 mL	0.2908 mL	0.5816 mL	2.9081 mL
100 mM	0.0291 mL	0.1454 mL	0.2908 mL	1.4540 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc