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Results for "Ras" in TargetMol Product Catalog
  • Inhibitor Products
    242
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RMC-6236
T746982765081-21-6
RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer.
  • $297
In Stock
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RAS GTPase inhibitor 1
T126922252242-32-1In house
RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.
  • $373 TargetMol
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Ras Inhibitory Peptide acetate
T37422L
Ras Inhibitory Peptide acetate is a peptide involved in the Ras-dependent signaling pathway that plays an important role in human cancers initiated by oncogenic receptors.
  • $195
In Stock
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K-Ras ligand-Linker Conjugate 6
T180592378261-89-1
K-Ras ligand-Linker Conjugate 6 is a chemical compound that combines a ligand for K-Ras recruiting moiety and a PROTAC linker. This compound can recruit E3 ligases, including VHL, CRBN, MDM2, and IAP. K-Ras ligand-Linker Conjugate 6 is particularly useful in the synthesis of PROTAC K-Ras Degrader-1, a highly effective K-Ras degrader that achieves ≥70% degradation efficacy in SW1573 cells[1].
  • $124
5 days
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QTY
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PROTAC K-Ras Degrader-1
T138442378258-52-5
PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC.
  • $456
Backorder
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K-Ras G12C-IN-4
T117382376328-55-9
K-Ras G12C-IN-4, is a potent Covalent Inhibitor of KRASG12C..
  • $148
In Stock
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Ras inhibitor 134
T778002648552-54-7
Ras inhibitor 134 can be used in studies about Ras.
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K-Ras(G12C) inhibitor 9
T65561469337-91-4
K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).
  • $48
In Stock
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Ras Inhibitory Peptide
T37422159088-48-9
Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2. It specifically blocks the interaction of the GEF with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases, including epidermal growth factor receptor.
  • $170
35 days
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QTY
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K-Ras(G12C) inhibitor 12
T65551469337-95-8
K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).
  • $48
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K-Ras ligand-Linker Conjugate 4
T180572378261-83-5
K-Ras ligand-Linker Conjugate 4 is a chemical compound that combines a ligand for K-Ras recruiting moiety with a PROTAC linker. This linker is responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. The compound has the potential to be used in the synthesis of PROTAC K-Ras Degrader-1, a powerful degrader of K-Ras that has been shown to exhibit a degradation efficacy of ≥70% in SW1573 cells[1].
  • $75
5 days
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6H05
T19311469338-01-9
6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
  • $129
4-6 weeks
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Ras modulator-1
T72774623935-08-0
Ras modulator-1 is a modulator of Ras.
  • $1,520
6-8 weeks
Size
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K-Ras-IN-1
T546984783-01-7
K-Ras-IN-1 is a K-Ras inhibitor.
  • $45
In Stock
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K-Ras G12C-IN-3
T117371629268-19-4
Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers.K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.
  • $347
6-8 weeks
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QTY
K-Ras ligand-Linker Conjugate 5
T180582378261-85-7
K-Ras ligand-Linker Conjugate 5 is a chemical compound that combines a ligand for the K-Ras recruiting moiety with a PROTAC linker. This linker is responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. The K-Ras ligand-Linker Conjugate 5 plays a crucial role in the synthesis of PROTAC K-Ras Degrader-1, a highly potent K-Ras degrader. In SW1573 cells, this degrader exhibits an impressive degradation efficacy of ≥70% [1].
  • $85
5 days
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K-Ras G12C-IN-1
T117351629265-17-3
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.
  • $1,530
8-10 weeks
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K-Ras G12C-IN-2
T117361629267-75-9
K-Ras G12C-IN-2 is a covalent kras g12c inhibitor.
  • $1,820
8-10 weeks
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Pan-RAS-IN-1
T164321835283-94-7
Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.
  • $73
In Stock
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RAS/RAS-RAF-IN-1
T366422447039-81-6
RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μμ-15 μμ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity[1]. RAS/RAS-RAF-IN-1 (compound 89; for 4 hours) has an EC50 of 0.5 μμ-5.0 μμ for BRAF-GTP-KRAS-G12C disruption and has an IC50 of 1.0 μμ-10 μμ for pERK inhibition in H358 cells[1]. [1]. Meizhong Jin, et al. Compounds that participate in cooperative binding and uses thereof. WO2020132597A1.
  • $1,160
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K-Ras ligand-Linker Conjugate 3
T180562378261-87-9
K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound that consists of a ligand for K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential in the synthesis of PROTAC K-Ras Degrader-1, a potent PROTAC K-Ras degrader that demonstrates a degradation efficacy of ≥70% in SW1573 cells[1].
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K-Ras ligand-Linker Conjugate 2
T18055
K-Ras ligand-Linker Conjugate 2 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker. This compound is capable of recruiting E3 ligases like VHL, CRBN, MDM2, and IAP. It is utilized in the synthesis of PROTAC K-Ras Degrader-1, which is a highly effective PROTAC K-Ras degrader with a degradation efficacy of ≥70% in SW1573 cells[1].
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G12
T39099162550-82-5
G12 (Ras 5-17) is a wild-type Ras peptide composed of amino acids 5-17, specifically KLVVVGAGGVGKS. It can serve as a control in studies focused on mutant Ras peptides, like V12.
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K-Ras-PDEδ-IN-1
T86591841464-21-8
K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).
  • $80
In Stock
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K-Ras ligand-Linker Conjugate 1
T18054
K-Ras ligand-Linker Conjugate 1 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker, facilitating the recruitment of E3 ligases VHL, CRBN, MDM2, and IAP. It can be utilized in the synthesis of PROTAC K-Ras Degrader-1, a highly effective K-Ras degrader that achieves ≥70% degradation efficacy in SW1573 cells[1].
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RAS inhibitor Abd-7
T366412351843-48-4
RAS inhibitor Abd-7 is a powerful compound (Kd=51 nM) that binds to RAS and inhibits the protein-protein interaction (PPI) between RAS and its effectors. By interacting with RAS within cells, RAS inhibitor Abd-7 hinders RAS-effector interactions and suppresses endogenous RAS-dependent signaling. Additionally, RAS inhibitor Abd-7 disrupts the PPI of different mutant KRAS proteins with PI3K, CRAF, RALGDS, as well as NRAS Q61H and HRAS G12V[1].
  • $233
5 days
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K-Ras(G12C) Inhibitor 6
T37252060530-16-5
K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 μM for 24 hours in vitro.
  • $57
In Stock
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Erastin
T1765571203-78-6
Erastin is an iron death activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner. Erastin has anti-tumor activity and acts selectively on tumor cells with RAS-carcinogenic mutations. The product is unstable in solution and is recommended to be dispensed now.
  • $41
In Stock
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TargetMol | Citations Cited
MRTX1133
T93032621928-55-8In house
MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors.
  • $197
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TargetMol | Inhibitor Hot
RSL3
T36461219810-16-8
RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of iron death that is selective for tumor cells carrying oncogenic RAS.
  • $33
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TargetMol | Citations Cited
SCH772984
T6066942183-80-4
SCH 772984 is a potent inhibitor of ERK1/ERK2 (IC50: 4/1 nM) and has only weak inhibitory for other 300 tested kinases.
  • $48
In Stock
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Sotorasib
T86842296729-00-3
Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib exhibits inhibitory activity against KRAS G12C mutant tumors.
  • $31
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Rhosin hydrochloride
T167451281870-42-5
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin h
  • $162
In Stock
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Adagrasib
T83692326521-71-3
Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Adagrasib exhibits inhibitory activity against KRAS G12C mutant tumors.
  • $59
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Y16
T3553429653-73-6
Y16 is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling functions.
  • $30
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TargetMol | Inhibitor Hot
Perillyl alcohol
T3314536-59-4
Perillyl Alcohol is a naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol (Isocarveol) inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing post-translational protein farnesylation and isoprenylation and activation of oncoproteins such as p21-ras, and arresting tumor cells in the G1 phase of the cell cycle.
  • $40
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(S)-(-)-Perillyl alcohol
T828218457-55-1
(S)-(-)-Perillyl alcohol (Perillyl alcohol) is a monoterpene extracted from Chamaecyparis obtusa with anticancer and neuroprotective activities.It inhibits farnesylation of Ras, up-regulates mannose 6-phosphate receptors and induces apoptosis.
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Sulindac sulfide
T1303749627-27-2In house
Sulindac sulfide (cis-Sulindac sulfide) is a non-steroidal anti-inflammatory compound that has a high affinity for COX-1 and acts as an inhibitor in Ras activation of Raf-1. Sulindac sulfide is a non-competitive inhibitor of gamma-secretase with an IC50 value of 20.2 μM. It is an active metabolite of sulinic acid.
  • $31
In Stock
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Deltarasin
T64621440898-61-2In house
Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
  • $38
In Stock
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magnolin
T385731008-18-1
Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects.
  • $93
In Stock
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KRPEP-2D acetate
TP2358
KRPEP-2D acetate was identified as a K-Ras(G12D) selective inhibitory peptide against the G12D mutant of K-Ras, which is a key member of the Ras protein family and an attractive cancer therapeutic target.
  • $76
In Stock
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Alamandine TFA
T37496L
Alamandine TFA , a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine TFA targets to protect the kidney and heart through anti-hypertensive actions[1][2].
  • $55
In Stock
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1-(4-methansulfinylphenyl)ethanone
T887032361-73-2
The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.
  • $78
In Stock
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DCAI
T23969299165-92-7
DCAI is an inhibitor of nucleotide exchange and nucleotide release acting by binding to the pocket adjacent to the Ras-SOS interface.
  • $117
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A-176120
T26469185049-54-1In house
A-176120 is a potent farnesyl pyrophosphate (FPP) analogues, it selectively inhibits farnesyltransferase. It has anti-angiogenic potential and may reduce H-ras NIH3T3 tumour growth.
  • $1,520
6-8 weeks
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p38 MAPK Inhibitor
T36010219138-24-6In house
p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.
  • $147
In Stock
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LB42708
T2678226929-39-1In house
LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras).
  • $42
In Stock
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(R)-BI-2852
T720842375482-49-6In house
(R)-BI-2852 can be used as (R)-5-isoindolin-1-one is used as an inhibitor of the RAS family of proteins and as a compound for the treatment and prevention of tumours. (R)-BI-2852 has Antiproliferative and antitumour agent activity.
  • $142
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BMS-214662
T10567195987-41-8In house
BMS-214662 is a potent and selective farnesyl transferase inhibitor that induces mitochondrial apoptosis in primitive CD34+ chronic myeloid leukemia (CML) stem cells/progenitors, and has the ability to selectively target CML stem cells/progenitors with antitumor activity.
  • $2,270
6-8 weeks
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XRP44X
T20759729605-21-4In house
XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.
  • $50
In Stock
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