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SNX0723

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Catalog No. T28824Cas No. 1073969-18-2
Alias SNX- 0723, SNX 0723

SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respectively. SNX0723 inhibits liver-stage P. berghei ANKA parasites with the EC50 of 3.3 μM.

SNX0723

SNX0723

😃Good
Purity: 99.85%
Catalog No. T28824Alias SNX- 0723, SNX 0723Cas No. 1073969-18-2
SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respectively. SNX0723 inhibits liver-stage P. berghei ANKA parasites with the EC50 of 3.3 μM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$82In StockIn Stock
5 mg$198In StockIn Stock
10 mg$333In StockIn Stock
25 mg$538In StockIn Stock
50 mg$738In StockIn Stock
100 mg$990In StockIn Stock
500 mgPreferential-In Stock
1 mL x 10 mM (in DMSO)$217In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly
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Purity:99.85%
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Product Introduction

Bioactivity
Description
SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respectively. SNX0723 inhibits liver-stage P. berghei ANKA parasites with the EC50 of 3.3 μM.
In vitro
SNX0723 inhibits P. falciparum Dd2 blood-stage parasites and P. berghei ANKA liver-stage parasites, EC50 are 7.4μM and 6.5μM, respectively[1].
SynonymsSNX- 0723, SNX 0723
Chemical Properties
Molecular Weight399.46
FormulaC22H26FN3O3
Cas No.1073969-18-2
SmilesCc1cn(c2CC(C)(C)CC(=O)c12)-c1cc(F)c(C(N)=O)c(N[C@H]2CCOC2)c1
Relative Density.1.37 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (150.2 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2.5 mg/mL (6.26 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5034 mL12.5169 mL25.0338 mL125.1690 mL
5 mM0.5007 mL2.5034 mL5.0068 mL25.0338 mL
10 mM0.2503 mL1.2517 mL2.5034 mL12.5169 mL
20 mM0.1252 mL0.6258 mL1.2517 mL6.2584 mL
50 mM0.0501 mL0.2503 mL0.5007 mL2.5034 mL
100 mM0.0250 mL0.1252 mL0.2503 mL1.2517 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SNX-0723SNX0723HSP90
Related Tags: buy SNX0723 | purchase SNX0723 | SNX0723 cost | order SNX0723 | SNX0723 chemical structure | SNX0723 in vitro | SNX0723 formula | SNX0723 molecular weight
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