S-MGB-234

Name: S-MGB-234
Brand: TargetMol
SKU: T39397
Rating: 4.5 (1 reviews)

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Catalog No. T39397Cas No. 1970223-53-0

S-MGB-234 is a minor groove binder used for treating Animal African Trypanosomiasis (AAT). It shows exceptional in vitro efficacy against the main causative agents, Trypanosoma congolense and Trypanosoma vivax, without demonstrating cross-resistance with existing diamidine drugs and is not internalized through the transporters used by diamidines.

S-MGB-234

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Catalog No. T39397Cas No. 1970223-53-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$1,520	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description	S-MGB-234 is a minor groove binder used for treating Animal African Trypanosomiasis (AAT). It shows exceptional in vitro efficacy against the main causative agents, Trypanosoma congolense and Trypanosoma vivax, without demonstrating cross-resistance with existing diamidine drugs and is not internalized through the transporters used by diamidines.
In vitro	S-MGB-234 (compound 7), with an exposure duration of 69 hours, exhibits non-toxic behavior towards L6 cells, demonstrating an effective concentration (EC 50) of 20.39 μM[1].
In vivo	S-MGB-234 (compound 7) effectively cures and prevents relapses in mice (cured/infected, 4/4) with two 50 mg/kg intraperitoneal (i.p.) doses. A partial cure (1/4) is achieved with four consecutive daily i.p. treatments of 10 mg/kg, while two 10 mg/kg i.p. doses do not cure but extend survival compared to untreated controls[1].

Chemical Properties

Molecular Weight	568.638
Formula	C₃₀H₃₂N₈O₄
Cas No.	1970223-53-0
Smiles	COc1ccc(\C=C\c2ccc(cn2)C(=O)Nc2cc(C(=O)Nc3cc(C(=O)NCCC(N)=N)n(C)c3)n(C)c2)cc1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc