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Proguanil

🥰Excellent
Catalog No. T22409Cas No. 500-92-5
Alias Chloroguanide, Chlorguanide

Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the dihydrofolate reductase (DHFR) enzyme of Plasmodium falciparum, preventing the synthesis of purines and pyrimidines and inhibiting the growth and reproduction of the parasite.

Proguanil
Other Forms of Proguanil:

Proguanil

🥰Excellent
Purity: 99.6%
Catalog No. T22409Alias Chloroguanide, ChlorguanideCas No. 500-92-5
Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the dihydrofolate reductase (DHFR) enzyme of Plasmodium falciparum, preventing the synthesis of purines and pyrimidines and inhibiting the growth and reproduction of the parasite.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$40-In Stock
25 mg$81-In Stock
50 mg$129-In Stock
100 mg$208-In Stock
1 mL x 10 mM (in DMSO)$59-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.6%
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Product Introduction

Bioactivity
Description
Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the dihydrofolate reductase (DHFR) enzyme of Plasmodium falciparum, preventing the synthesis of purines and pyrimidines and inhibiting the growth and reproduction of the parasite.
In vivo
Proguanil (2.9 mg/kg, orally, once daily) treatment of Wistar albino rats showed mild degenerative changes at day 5 and severe degenerative changes within 6 weeks, and resulted in a significant decrease in serum testosterone levels in the rats. [4]
SynonymsChloroguanide, Chlorguanide
Chemical Properties
Molecular Weight253.73
FormulaC11H16ClN5
Cas No.500-92-5
SmilesClC1=CC=C(C=C1)NC(=N)NC(=N)NC(C)C
Relative Density.1.29g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 40 mg/mL (157.65 mM), Sonication is recommended.
DMSO: 120 mg/mL (472.94 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (15.76 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM3.9412 mL19.7060 mL39.4120 mL197.0599 mL
5 mM0.7882 mL3.9412 mL7.8824 mL39.4120 mL
10 mM0.3941 mL1.9706 mL3.9412 mL19.7060 mL
20 mM0.1971 mL0.9853 mL1.9706 mL9.8530 mL
50 mM0.0788 mL0.3941 mL0.7882 mL3.9412 mL
100 mM0.0394 mL0.1971 mL0.3941 mL1.9706 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Proguanil
Related Tags: buy Proguanil | purchase Proguanil | Proguanil cost | order Proguanil | Proguanil chemical structure | Proguanil in vivo | Proguanil formula | Proguanil molecular weight
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