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Proguanil

Name: Proguanil
Brand: TargetMol
SKU: T22409
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22409Cas No. 500-92-5

Alias Chloroguanide, Chlorguanide

Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the dihydrofolate reductase (DHFR) enzyme of Plasmodium falciparum, preventing the synthesis of purines and pyrimidines and inhibiting the growth and reproduction of the parasite.

Proguanil

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Purity: 99.6%

Catalog No. T22409Alias Chloroguanide, ChlorguanideCas No. 500-92-5

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$40	-	In Stock
25 mg	$81	-	In Stock
50 mg	$129	-	In Stock
100 mg	$176	-	In Stock
1 mL x 10 mM (in DMSO)	$59	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.6%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the dihydrofolate reductase (DHFR) enzyme of Plasmodium falciparum, preventing the synthesis of purines and pyrimidines and inhibiting the growth and reproduction of the parasite.
In vivo	Proguanil (2.9 mg/kg, orally, once daily) treatment of Wistar albino rats showed mild degenerative changes at day 5 and severe degenerative changes within 6 weeks, and resulted in a significant decrease in serum testosterone levels in the rats. [4]
Synonyms	Chloroguanide, Chlorguanide

Chemical Properties

Molecular Weight	253.73
Formula	C₁₁H₁₆ClN₅
Cas No.	500-92-5
Smiles	ClC1=CC=C(C=C1)NC(=N)NC(=N)NC(C)C
Relative Density.	1.29g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 40 mg/mL (157.65 mM), Sonication is recommended.

DMSO: 120 mg/mL (472.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (15.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9412 mL	19.7060 mL	39.4120 mL	197.0599 mL
5 mM	0.7882 mL	3.9412 mL	7.8824 mL	39.4120 mL
10 mM	0.3941 mL	1.9706 mL	3.9412 mL	19.7060 mL
20 mM	0.1971 mL	0.9853 mL	1.9706 mL	9.8530 mL
50 mM	0.0788 mL	0.3941 mL	0.7882 mL	3.9412 mL
100 mM	0.0394 mL	0.1971 mL	0.3941 mL	1.9706 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc