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Lactupicrin

Name: Lactupicrin
Brand: TargetMol
SKU: TN4403
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN4403Cas No. 65725-11-3

Alias Lactucopicrin

Lactupicrin is a natural product discovered in chicory, exhibiting analgesic, sedative, antimalarial, and anti-atherosclerotic effects. It inhibits NF-κB activation and LDLR1 production, and demonstrates inhibitory activity against yeast alpha-glucosidase (IC50 = 14.71 µM).

Lactupicrin

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Purity: 99.97%

Catalog No. TN4403Alias LactucopicrinCas No. 65725-11-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$147	-	In Stock
5 mg	$372	-	In Stock
10 mg	$619	-	In Stock
25 mg	$965	-	In Stock
50 mg	$1,280	-	In Stock
100 mg	$1,750	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.97%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Lactupicrin is a natural product discovered in chicory, exhibiting analgesic, sedative, antimalarial, and anti-atherosclerotic effects. It inhibits NF-κB activation and LDLR1 production, and demonstrates inhibitory activity against yeast alpha-glucosidase (IC50 = 14.71 µM).
Targets&IC50	acetylcholinesterase (AChE):150.3 μM
In vitro	Lactupicrin (0.25-1 μM, 24 hours) attenuates cholesterol influx into low-grade inflammatory macrophages by targeting LOX-1 [2]. In inflammatory macrophages, Lactupicrin (0.625-40 μM, 24 hours) inhibits the activity of NF-κB within inflammatory macrophages [3]. In inflammatory macrophages, Lactupicrin (40 μM, 24 hours) suppresses the nuclear translocation process of p65 by downregulating cytoplasmic dynein-mediated transport of p65 [3]. Lactupicrin (50 μg/L, 48 hours) exhibits complete inhibitory effects on parasite growth [4]. Lactupicrin (10-1000 μM, 45 minutes) dose-dependently inhibits AChE activity [4].
In vivo	Lactupicrin (15-30 mg/kg, intraperitoneal injection) exhibits analgesic activity and sedative properties in mice [1]. In ApoE-/- mice, Lactupicrin (1.2-120 mg/kg, oral administration, once daily for 12 weeks) exerts its anti-atherosclerotic effects by reducing LOX-1 in lipid rafts, thereby inhibiting macrophage foam cell formation [2]. In ApoE-/- mice, Lactupicrin (1.2-120 mg/kg, oral administration, once daily for 12 weeks) can suppress early atherosclerosis formation [3]. In ApoE-/- mice, Lactupicrin (1.2-120 mg/kg, oral administration, once daily for 12 weeks) dose-dependently reduces serum levels of IL-1β and TNF-α, but does not lower IL-6 levels [3].
Synonyms	Lactucopicrin

Chemical Properties

Molecular Weight	410.42
Formula	C₂₃H₂₂O₇
Cas No.	65725-11-3
Smiles	C(O)C=1[C@@]2([C@@]3([C@@]([C@@H](OC(CC4=CC=C(O)C=C4)=O)CC(C)=C2C(=O)C1)(C(=C)C(=O)O3)[H])[H])[H]
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (487.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4365 mL	12.1826 mL	24.3653 mL	121.8264 mL
5 mM	0.4873 mL	2.4365 mL	4.8731 mL	24.3653 mL
10 mM	0.2437 mL	1.2183 mL	2.4365 mL	12.1826 mL
20 mM	0.1218 mL	0.6091 mL	1.2183 mL	6.0913 mL
50 mM	0.0487 mL	0.2437 mL	0.4873 mL	2.4365 mL
100 mM	0.0244 mL	0.1218 mL	0.2437 mL	1.2183 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc