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Sandoz 58-035

Name: Sandoz 58-035
Brand: TargetMol
SKU: T88328
Price: 313 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Sandoz58-035) Copy Product Info

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Synonyms: Sandoz58-035

Catalog No. T88328 Copy Product Info

Purity: 99.83%

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Sandoz 58-035 acts as a competitive inhibitor of cholesterol acyltransferase (ACAT), significantly blocking (>98%) the hormonally stimulated esterification of cholesterol within cells. Sandoz 58-035 is therefore used in lipid metabolism and enzymology research systems to investigate ACAT-dependent cholesterol esterification processes, intracellular cholesterol trafficking, and regulation of sterol storage pathways in cellular models of lipid homeostasis.

Cas No. 78934-83-5

Pack Size	Price	USA Stock	Global Stock
1 mg	$89	-	In Stock
5 mg	$189	-	In Stock
10 mg	$313	-	In Stock
25 mg	Preferential	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.83%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Sandoz 58-035 acts as a competitive inhibitor of cholesterol acyltransferase (ACAT), significantly blocking (>98%) the hormonally stimulated esterification of cholesterol within cells. Sandoz 58-035 is therefore used in lipid metabolism and enzymology research systems to investigate ACAT-dependent cholesterol esterification processes, intracellular cholesterol trafficking, and regulation of sterol storage pathways in cellular models of lipid homeostasis.
In vivo	Method: Granulosa cells were cultured under limited or no serum conditions and treated long-term (2–6 days) with ACAT inhibitor Sandoz 58-035. Progesterone production was measured under basal conditions and after stimulation with estradiol, FSH, estradiol+FSH, or insulin. LDL was used as exogenous cholesterol. Acute (2–20 h) effects were also tested in swine and hamster ovarian cells. Result: Long-term treatment with Sandoz 58-035 significantly increased basal progesterone production and amplified hormone-stimulated progesterone production by 2–10 fold. The effect was mimicked by LDL, and co-treatment with LDL and Sandoz 58-035 did not further increase steroidogenesis. Acute (2–20 h) treatment did not alter progesterone biosynthesis in swine or hamster ovarian cells.
Synonyms	Sandoz58-035

Chemical Properties

Molecular Weight	465.79
Formula	C₃₀H₄₇NOSi
Cas No.	78934-83-5
Smiles	O=C(NC(C=1C=CC=CC1)CC2=CC=C(C=C2)C)CC[Si](C)(C)CCCCCCCCCC

Storage & Solubility Information

Storage

Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (171.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1469 mL	10.7345 mL	21.4689 mL	107.3445 mL
5 mM	0.4294 mL	2.1469 mL	4.2938 mL	21.4689 mL
10 mM	0.2147 mL	1.0734 mL	2.1469 mL	10.7345 mL
20 mM	0.1073 mL	0.5367 mL	1.0734 mL	5.3672 mL
50 mM	0.0429 mL	0.2147 mL	0.4294 mL	2.1469 mL
100 mM	0.0215 mL	0.1073 mL	0.2147 mL	1.0734 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: Sandoz 58-035 chemical structure | Sandoz 58-035 in vivo | Sandoz 58-035 formula | Sandoz 58-035 molecular weight