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Tetradifon

Name: Tetradifon
Brand: TargetMol
SKU: T20559
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20559Cas No. 116-29-0

Alias Roztozol, Roztoczol extra, Roztoczol

Tetradifon is a broad-spectrum organochlorine acaricide insecticide and a potent inhibitor of the mitochondrial oligomycin sensitivity conferring protein (OSCP)，a subunit of ATP synthase. Tetradifon is utilized for controlling a variety of mite pests and inhibiting energy-related mitochondrial activities including ADP-stimulated respiration and ATPase activity with an IC50 range of 4.5-27 nmoL/mg mitochondrial protein; it exerts oligomycin-like effects by inhibiting oxidative phosphorylation, inducing significant oxidative stress, and interfering with bone metabolism, making it a compound of interest for researching mitochondrial function, bone remodeling mechanisms, and nephrotoxicity.

Tetradifon

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Purity: 99.84%

Catalog No. T20559Alias Roztozol, Roztoczol extra, RoztoczolCas No. 116-29-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.84%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Tetradifon is a broad-spectrum organochlorine acaricide insecticide and a potent inhibitor of the mitochondrial oligomycin sensitivity conferring protein (OSCP)，a subunit of ATP synthase. Tetradifon is utilized for controlling a variety of mite pests and inhibiting energy-related mitochondrial activities including ADP-stimulated respiration and ATPase activity with an IC50 range of 4.5-27 nmoL/mg mitochondrial protein; it exerts oligomycin-like effects by inhibiting oxidative phosphorylation, inducing significant oxidative stress, and interfering with bone metabolism, making it a compound of interest for researching mitochondrial function, bone remodeling mechanisms, and nephrotoxicity.
In vivo	Tetradifon (24.3 mg/kg, oral gavage, 90 days) treatment of female Wistar rats showed an increase in creatinine/urea levels by 24%/43% at week 12, an increase in glomerular sclerosis rate to 22%, an increase in interstitial fibrosis index by 200%, a decrease in renal SOD/GPx activity by 32%/17%, and a decrease in vitamin C content by 31%. [5]
Synonyms	Roztozol, Roztoczol extra, Roztoczol

Chemical Properties

Molecular Weight	356.05
Formula	C₁₂H₆Cl₄O₂S
Cas No.	116-29-0
Smiles	O=S(=O)(C1=CC=C(Cl)C=C1)C2=CC(Cl)=C(Cl)C=C2Cl
Relative Density.	1.5630 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (112.34 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (5.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8086 mL	14.0430 mL	28.0859 mL	140.4297 mL
5 mM	0.5617 mL	2.8086 mL	5.6172 mL	28.0859 mL
10 mM	0.2809 mL	1.4043 mL	2.8086 mL	14.0430 mL
20 mM	0.1404 mL	0.7021 mL	1.4043 mL	7.0215 mL
50 mM	0.0562 mL	0.2809 mL	0.5617 mL	2.8086 mL
100 mM	0.0281 mL	0.1404 mL	0.2809 mL	1.4043 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc