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Primaquine

🥰Excellent
Catalog No. T60411Cas No. 90-34-6

Primaquine is an antimalarial compound and a gametocytocide, clearing liver schizonts and dormant forms of Plasmodium vivax.

Primaquine

Primaquine

🥰Excellent
Purity: 98.62%
Catalog No. T60411Cas No. 90-34-6
Primaquine is an antimalarial compound and a gametocytocide, clearing liver schizonts and dormant forms of Plasmodium vivax.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$31In StockIn Stock
50 mg$42In Stock-
100 mg$50In Stock-
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.62%
Appearance:Viscous
Color:Brown
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Product Introduction

Bioactivity
Description
Primaquine is an antimalarial compound and a gametocytocide, clearing liver schizonts and dormant forms of Plasmodium vivax.
Targets&IC50
EphB3:0.079 µM
In vitro
Methods: MDA-MB-231, HCC1937, MCF-7 and MDA-MB-453 cells were treated with Primaquine (5 μM, 10 μM, 20 μM, 40 μM, 80 μM, 100 μM, 120 μM and 150 μM for 24 hours) following the CellTiter 96® Aqueous One Solution Cell Kit protocol and the absorbance was read at 490 nm using SpectraMax.
Results: Primaquine inhibited breast cancer cells with an IC50 value of 81.2 μM and had no inhibitory effect on the proliferation of MCF-7 (ER+) and MDA-MB-453 (HER2+) cells. [1]
In vivo
Methods: Twelve 4-week-old nude mice were injected with MDA-MB-231 cells and treated with Primaquine (2 mg/kg). Tumor volume was measured every 10 days after 90 days using the formula.
Results: Primaquine inhibited tumor growth in a xenograft mouse model. [1]
Chemical Properties
Molecular Weight259.35
FormulaC15H21N3O
Cas No.90-34-6
SmilesN=1C=CC=C2C=C(OC)C=C(NC(C)CCCN)C12
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 257.5 mg/mL (992.87 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.8558 mL19.2790 mL38.5579 mL192.7897 mL
5 mM0.7712 mL3.8558 mL7.7116 mL38.5579 mL
10 mM0.3856 mL1.9279 mL3.8558 mL19.2790 mL
20 mM0.1928 mL0.9639 mL1.9279 mL9.6395 mL
50 mM0.0771 mL0.3856 mL0.7712 mL3.8558 mL
100 mM0.0386 mL0.1928 mL0.3856 mL1.9279 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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