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Primaquine is an antimalarial compound and a gametocytocide, clearing liver schizonts and dormant forms of Plasmodium vivax.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $31 | In Stock | In Stock | |
| 50 mg | $42 | In Stock | - | |
| 100 mg | $50 | In Stock | - |
| Description | Primaquine is an antimalarial compound and a gametocytocide, clearing liver schizonts and dormant forms of Plasmodium vivax. |
| Targets&IC50 | EphB3:0.079 µM |
| In vitro | Methods: MDA-MB-231, HCC1937, MCF-7 and MDA-MB-453 cells were treated with Primaquine (5 μM, 10 μM, 20 μM, 40 μM, 80 μM, 100 μM, 120 μM and 150 μM for 24 hours) following the CellTiter 96® Aqueous One Solution Cell Kit protocol and the absorbance was read at 490 nm using SpectraMax. Results: Primaquine inhibited breast cancer cells with an IC50 value of 81.2 μM and had no inhibitory effect on the proliferation of MCF-7 (ER+) and MDA-MB-453 (HER2+) cells. [1] |
| In vivo | Methods: Twelve 4-week-old nude mice were injected with MDA-MB-231 cells and treated with Primaquine (2 mg/kg). Tumor volume was measured every 10 days after 90 days using the formula. Results: Primaquine inhibited tumor growth in a xenograft mouse model. [1] |
| Molecular Weight | 259.35 |
| Formula | C15H21N3O |
| Cas No. | 90-34-6 |
| Smiles | N=1C=CC=C2C=C(OC)C=C(NC(C)CCCN)C12 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 257.5 mg/mL (992.87 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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