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Primaquine

🥰Excellent
Catalog No. T60411Cas No. 90-34-6

Primaquine is an antimalarial compound and a gametocytocide, clearing liver schizonts and dormant forms of Plasmodium vivax.

Primaquine
Other Forms of Primaquine:

Primaquine

🥰Excellent
Purity: 98.62%
Catalog No. T60411Cas No. 90-34-6
Primaquine is an antimalarial compound and a gametocytocide, clearing liver schizonts and dormant forms of Plasmodium vivax.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$31In StockIn Stock
50 mg$42In StockIn Stock
100 mg$50In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.62%
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Product Introduction

Bioactivity
Description
Primaquine is an antimalarial compound and a gametocytocide, clearing liver schizonts and dormant forms of Plasmodium vivax.
Targets&IC50
EphB3:0.079 µM
In vitro
Methods: MDA-MB-231, HCC1937, MCF-7 and MDA-MB-453 cells were treated with Primaquine (5 μM, 10 μM, 20 μM, 40 μM, 80 μM, 100 μM, 120 μM and 150 μM for 24 hours) following the CellTiter 96® Aqueous One Solution Cell Kit protocol and the absorbance was read at 490 nm using SpectraMax.
Results: Primaquine inhibited breast cancer cells with an IC50 value of 81.2 μM and had no inhibitory effect on the proliferation of MCF-7 (ER+) and MDA-MB-453 (HER2+) cells. [1]
In vivo
Methods: Twelve 4-week-old nude mice were injected with MDA-MB-231 cells and treated with Primaquine (2 mg/kg). Tumor volume was measured every 10 days after 90 days using the formula.
Results: Primaquine inhibited tumor growth in a xenograft mouse model. [1]
Chemical Properties
Molecular Weight259.35
FormulaC15H21N3O
Cas No.90-34-6
SmilesN=1C=CC=C2C=C(OC)C=C(NC(C)CCCN)C12
ColorBrown
AppearanceViscous
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 200 mg/mL (771.16 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.8558 mL19.2790 mL38.5579 mL192.7897 mL
5 mM0.7712 mL3.8558 mL7.7116 mL38.5579 mL
10 mM0.3856 mL1.9279 mL3.8558 mL19.2790 mL
20 mM0.1928 mL0.9639 mL1.9279 mL9.6395 mL
50 mM0.0771 mL0.3856 mL0.7712 mL3.8558 mL
100 mM0.0386 mL0.1928 mL0.3856 mL1.9279 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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